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A new and facile synthesis of quinazoline-2,4(1H,3H)-diones.

Organic letters (2009-02-26)
Jiarong Li, Xian Chen, Daxin Shi, Shuling Ma, Qing Li, Qi Zhang, Jianhong Tang
PMID19239261
ABSTRACT

A new and facile preparation of quinazoline-2,4(1H,3H)-diones was first reported which was the condensation of aromatic o-aminonitriles with DMF or N,N-diethylformamide in the presence of ZnCl(2) (0.5-10 mol %) at 190-200 degrees C in the sealed reactor.

MATERIALS
Product Number
Brand
Product Description
186317
Sigma-Aldrich
N,N-Diethylformamide, 99%