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The Japanese toxicogenomics project: application of toxicogenomics.

Molecular nutrition & food research (2009-12-31)
Takeki Uehara, Atsushi Ono, Toshiyuki Maruyama, Ikuo Kato, Hiroshi Yamada, Yasuo Ohno, Tetsuro Urushidani
ABSTRACT

Biotechnology advances have provided novel methods for the risk assessment of chemicals. The application of microarray technologies to toxicology, known as toxicogenomics, is becoming an accepted approach for identifying chemicals with potential safety problems. Gene expression profiling is expected to identify the mechanisms that underlie the potential toxicity of chemicals. This technology has also been applied to identify biomarkers of toxicity to predict potential hazardous chemicals. Ultimately, toxicogenomics is expected to aid in risk assessment. The following discussion explores potential applications and features of the Japanese Toxicogenomics Project.

MATERIALS
Product Number
Brand
Product Description

Supelco
Cyclosporin A, VETRANAL®, analytical standard
Supelco
Ibuprofen
Supelco
Melting point standard 235-237°C, analytical standard
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Nicotinic acid, analytical standard
Supelco
Ethanol solution, certified reference material, 2000 μg/mL in methanol
Sigma-Aldrich
Bromobenzene, ≥99.5% (GC)
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Tannic acid, ACS reagent
Sigma-Aldrich
Bromobenzene, ReagentPlus®, 99%
Sigma-Aldrich
2-Mercapto-1-methylimidazole, ≥99%
Sigma-Aldrich
Nicotinic acid, ≥99.5% (HPLC)
Sigma-Aldrich
Cyclosporin A, 97.0-101.5% (on dried basis)
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17α-Methyltestosterone, VETRANAL®, analytical standard
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Nitrofurantoin, VETRANAL®, analytical standard
Sigma-Aldrich
Phenacetin, ≥98.0% (HPLC)
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Coumarin, ≥99% (HPLC)
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Nicotinic acid, ≥98%
Sigma-Aldrich
Nicotinic acid, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥98%
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Nicotinic acid, meets USP testing specifications
Sigma-Aldrich
2-Propylpentanoic acid
Sigma-Aldrich
Acetylsalicylic acid, ≥99.0%
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Indomethacin, meets USP testing specifications
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Nitrofurantoin, 98.0-102.0% (EP, UV)
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Indomethacin, 98.5-100.5% (in accordance with EP)
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17α-Ethynylestradiol, ≥98%
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Nifedipine, ≥98% (HPLC), powder
Supelco
Methimazole, analytical standard
Sigma-Aldrich
(±)-Sulpiride
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Theophylline, anhydrous, ≥99%, powder
Sigma-Aldrich
Cyclosporin A, BioReagent, from Tolypocladium inflatum, for molecular biology, ≥95%
Sigma-Aldrich
Cyclosporin A, from Tolypocladium inflatum, ≥95% (HPLC), solid