- Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases.
Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases.
Bioorganic & medicinal chemistry (2009-11-17)
Igor Beseda, Laszlo Czollner, Priti S Shah, Rupesh Khunt, Rawindra Gaware, Paul Kosma, Christian Stanetty, Maria Carmen Del Ruiz-Ruiz, Hassan Amer, Kurt Mereiter, Thierry Da Cunha, Alex Odermatt, Dirk Classen-Houben, Ulrich Jordis
PMID19914836
ABSTRACT
The effect of glycyrrhetinic acid (GA) and GA-derivatives towards 11beta-hydroxysteroid dehydrogenase (11beta-HSD) was investigated. Novel compounds with modifications at positions C-3, C-11 and C-29 of the GA skeleton were prepared. Single crystal X-ray diffraction data of selected substances are reported and discussed.
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