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  • Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase.

Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase.

Bioorganic & medicinal chemistry letters (2008-05-24)
Suresh K Tipparaju, Sipak Joyasawal, Sara Forrester, Debbie C Mulhearn, Scott Pegan, Michael E Johnson, Andrew D Mesecar, Alan P Kozikowski
PMID18499454
ABSTRACT

Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of BaENR.