- Intracellular location matters: rationalization of the anti-inflammatory activity of a manganese(ii) superoxide dismutase mimic complex.
Intracellular location matters: rationalization of the anti-inflammatory activity of a manganese(ii) superoxide dismutase mimic complex.
Chemical communications (Cambridge, England) (2020-06-11)
Emilie Mathieu, Anne-Sophie Bernard, Elodie Quévrain, Martha Zoumpoulaki, Sébastien Iriart, Caroline Lung-Soong, Barry Lai, Kadda Medjoubi, Lucas Henry, Sounderya Nagarajan, Florent Poyer, Andreas Scheitler, Ivana Ivanović-Burmazović, Sergio Marco, Andrea Somogyi, Philippe Seksik, Nicolas Delsuc, Clotilde Policar
PMID32520039
ABSTRACT
A conjugate of a Mn-based superoxide dismutase mimic with a Re-based multimodal probe 1[combining low line] was studied in a cellular model of oxidative stress. Its speciation was investigated using Re and Mn X-fluorescence. Interestingly, 1[combining low line] shows a distribution different from its unconjugated analogue but a similar concentration in mitochondria and a similar bioactivity.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Anti-COX2 antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody