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Merck

TGFBR1

transforming growth factor, beta receptor 1

Synonyms:
AAT5, ACVRLK4, ALK-5, ALK5, LDS1A, LDS2A, MSSE, SKR4, TGFR-1
Species:
Human TGFBR1 (7046), Mouse Tgfbr1 (21812), Rat Tgfbr1 (29591), chicken TGFBR1 (374094), dog TGFBR1 (481628), sheep TGFBR1 (554326), cow TGFBR1 (282382), domestic cat TGFBR1 (101094057), naked mole-rat Tgfbr1 (101718090), domestic guinea pig Tgfbr1 (100715237)
UniProtKB ID:
P36897, Q6IR47, Q706C0, Q706C1
Gene ID:
  • Human(7046) Summary: The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
  • Mouse(21812) transforming growth factor, beta receptor I
  • Rat(29591) transforming growth factor, beta receptor 1
  • chicken(374094) transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)
  • dog(481628) transforming growth factor, beta receptor 1
  • sheep(554326) transforming growth factor, beta receptor 1
  • cow(282382) transforming growth factor, beta receptor 1
  • domestic cat(101094057) transforming growth factor, beta receptor 1
  • naked mole-rat(101718090) transforming growth factor, beta receptor 1
  • domestic guinea pig(100715237) transforming growth factor, beta receptor 1

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB4502958
Anti-TGF β Receptor I antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
western blot
ZRB2469
Anti-TGF β receptor 1 Antibody, clone 4H18 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human
Application
ELISA
affinity binding assay
immunocytochemistry
western blot
SAB5700651
Anti-TGFBR1 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
SAB2501771
Anti-TGFBR1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, rat
Application
ELISA
flow cytometry
immunohistochemistry
western blot
SAB1306391
ANTI-TGF BETA RECEPTOR I (CENTER) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
L6293
LY-364947, ≥98% (HPLC),
Species
human

Proteins

Product Number
Description
Species
SRP5145
TGFβR1 (80-end), GST tagged human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
SRP5091
TGFβR1 (80-end), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human

esiRNA

Product Number
Description
Species
EMU051041
MISSION® esiRNA, targeting mouse Tgfbr1,
Species
mouse
EHU051131
MISSION® esiRNA, targeting human TGFBR1,
Species
human