SPAG1
sperm associated antigen 1
Synonyms:
HSD-3.8, SP75, TPIS
Species:
Human SPAG1 (6674), Mouse Spag1 (26942), Rat Spag1 (315033), sheep SPAG1 (101104833), naked mole-rat Spag1 (101713115), domestic guinea pig Spag1 (100728301), cow SPAG1 (530104), dog SPAG1 (607063), chicken SPAG1 (420249), domestic cat SPAG1 (101082465)
UniProtKB ID:
Gene ID:
- Human(6674) Summary: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein. [provided by RefSeq, Jul 2008]
- Mouse(26942) sperm associated antigen 1
- Rat(315033) sperm associated antigen 1
- sheep(101104833) sperm associated antigen 1
- naked mole-rat(101713115) sperm associated antigen 1
- domestic guinea pig(100728301) sperm associated antigen 1
- cow(530104) sperm associated antigen 1
- dog(607063) sperm associated antigen 1
- chicken(420249) sperm associated antigen 1
- domestic cat(101082465) sperm associated antigen 1
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Antibodies
Product Number
Description
Species Reactivity
Application
ANTI-SPAG1 (N-TERM) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-SPAG1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry