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Merck

PARK2

parkinson protein 2, E3 ubiquitin protein ligase (parkin)

Synonyms:
AR-JP, LPRS2, PDJ, PRKN
Species:
UniProtKB ID:
Gene ID:
  • Human(5071) Summary: The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008]
  • Mouse(50873) Parkinson disease (autosomal recessive, juvenile) 2, parkin
  • Rat(56816) parkinson protein 2, E3 ubiquitin protein ligase
  • cow(530858) parkinson protein 2, E3 ubiquitin protein ligase (parkin)
  • naked mole-rat(101700770) parkinson protein 2, E3 ubiquitin protein ligase (parkin)
  • domestic guinea pig(100724550) parkinson protein 2, E3 ubiquitin protein ligase (parkin)
  • Horse(100057832) parkinson protein 2, E3 ubiquitin protein ligase (parkin)
  • Zebrafish(550328) Parkinson disease (autosomal recessive, juvenile) 2, parkin
  • chicken(421577) parkinson protein 2, E3 ubiquitin protein ligase (parkin)
  • dog(612316) parkinson protein 2, E3 ubiquitin protein ligase (parkin)
  • domestic cat(101098228) parkinson protein 2, E3 ubiquitin protein ligase (parkin)
  • sheep(101113503) parkinson protein 2, E3 ubiquitin protein ligase (parkin)

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Antibodies

Product Number
Description
Species Reactivity
Application
ANTI-PARKIN(C-TERMINAL) antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse
Application
flow cytometry
immunofluorescence

immunohistochemistry

western blot
Anti-Parkin antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot
Anti-phospho-Parkin (pSer131) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
Anti-PARK2 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human, mouse, rat
Application
ELISA
western blot
Anti-Parkin Antibody, clone PRK8, ascites fluid, clone PRK8, Upstate®,
Species Reactivity
human, mouse
Application
immunocytochemistry
immunohistochemistry

immunoprecipitation (IP)

western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human PARK2,
Species
human