HIF1A
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Synonyms:
HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78
Species:
Human HIF1A (3091), Mouse Hif1a (15251), Rat Hif1a (29560), dog HIF1A (480348), domestic guinea pig Hif1a (100713113), naked mole-rat Hif1a (101715845), Domestic Rabbit HIF1A (100009579), sheep HIF1A (443519), cow HIF1A (281814), domestic cat HIF1A (101083686)
UniProtKB ID:
Gene ID:
- Human(3091) Summary: This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]
- Mouse(15251) hypoxia inducible factor 1, alpha subunit
- Rat(29560) hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
- dog(480348) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
- domestic guinea pig(100713113) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
- naked mole-rat(101715845) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
- Domestic Rabbit(100009579) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
- sheep(443519) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
- cow(281814) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
- domestic cat(101083686) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
- chicken(374177) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
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ELISA
Product Number
Description
Species
Human HIF-1 alpha ELISA Kit, for cell culture supernatants, plasma, and serum samples,
Species
human
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-HIF-1α Antibody, clone 2B14 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, monkey
Application
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Monoclonal Anti-HIF1A, (C-terminal) antibody produced in mouse, clone 1D4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
proximity ligation assay
western blot
proximity ligation assay
western blot
Monoclonal Anti-HIF-1α antibody produced in mouse, ~1 mg/mL, clone OZ12, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
immunoprecipitation (IP)
immunoprecipitation (IP)
Monoclonal Anti-HIF-1 α antibody produced in mouse, clone ESEE122, 1 mg/mL, purified immunoglobulin,
Species Reactivity
bovine, human, mouse, rat
Application
ELISA
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
Anti-HIF-1α Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
human
Application
western blot
Proteins
Product Number
Description
Species
HIF-1 α N-terminal activation domain (530-698) human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE),
Species
human