SAB5600015

Anti-Acetyl-Histone H3 (Lys56) antibody, Rabbit monoclonal

recombinant, expressed in HEK 293 cells, clone RM179, purified immunoglobulin

• Synonym(s): H3K56ac, Histone H3 (acetyl K56)
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• recombinant: expressed in HEK 293 cells
• Quality Level: 100
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: RM179, monoclonal; recombinant monoclonal
• form: buffered aqueous glycerol solution
• species reactivity: human
• concentration: ~1 mg/mL
• technique(s): ELISA: 0.5-1 μg/mL; immunocytochemistry: 0.5-2 μg/mL; immunohistochemistry: 1 ug/mL – 10 ug/mL; western blot: 1-2 μg/mL
• isotype: IgG
• NCBI accession no.: 8350
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: acetylation (Lys56)
• Gene Information: human ... H3C1(8350)

Description

General description

Mammals contain three main classes of histone H3 variants: the replicative histones (H3.1 and H3.2), the replacement histone (H3.3) and the centromeric histone (Cenp-A). Histone H3 is located on human chromosome 6p22.

Specificity

This antibody reacts to Histone H3 acetylated at Lysine 56 (K56ac). No cross reactivity with other acetylated Lysines in histone H3.

Immunogen

Synthetic peptide corresponding to the Acetyl-Histone H3 (Lys56)

Biochem/physiol Actions

Histone proteins are basic building blocks of chromatin. Histone H3 K27M mutations in adult cerebellar high-grade gliomas. It controls protein-protein interactions to induce binding of trans-acting factors that drive chromatin condensation.

Features and Benefits

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Physical form

Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable