SAB4700048
Monoclonal Anti-CD3-FITC antibody produced in mouse
clone MEM-57, purified immunoglobulin, buffered aqueous solution
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.44
Recommended Products
biological source
mouse
Quality Level
conjugate
FITC conjugate
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
MEM-57, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
flow cytometry: suitable
isotype
IgG2a
NCBI accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... CD3E(916)
General description
CD3 molecule is encoded by the gene mapped to human chromosome 11q23.3. The encoded protein exists in three isoforms, CD3ε, CD3γ and CD3δ and each contains an N-terminal extracellular domain, a transmembrane segment and a cytoplasmic domain. CD3 is a 20kDa glycoprotein expressed on surface of all human T lymphocytes.
The antibody MEM-57 reacts with gamma-epsilon and delta-epsilon dimers of human CD3 complex, a part of a bigger multisubunit T cell receptor complex (CD3/TCR) expressed on peripheral blood T lymphocytes and mature thymocytes.
Immunogen
Human thymocytes and T lymphocytes
Application
The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.
Biochem/physiol Actions
T-cell receptor-CD3 complex containing CD3ε, CD3γ and CD3δ, is essentially involved in inducing early metabolic events that lead to T-cell activation. Mutation in the CD3ε has been observed in T-B+ NK+ severe combined immunodeficiency (SCID) patients.
Features and Benefits
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Physical form
Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
The T cell receptor/CD3 complex: a dynamic protein ensemble.
Clevers H
Annual Review of Immunology, 629-662 (1988)
Lito A Papaxenopoulou et al.
iScience, 25(12), 105522-105522 (2022-11-30)
Staphylococcus aureus can lead to chronic infections and abscesses in internal organs including kidneys, which are associated with the expansion of myeloid-derived suppressor cells (MDSCs) and their suppressive effect on T cells. Here, we developed a mathematical model of chronic
Most Jacobsen Syndrome Deletion Breakpoints
Occur Distal to FRA11B
Michaelis RC
American Journal of Medical Genetics, 76, 222-228 (1998)
Notch signaling induces cytoplasmic CD3 epsilon expression in human differentiating NK cells.
De Smedt M
Blood, 110, 2696-2703 (2007)
A novel pathogenic frameshift variant of CD3E gene in two T-B+ NK+ SCID patients from Turkey.
Firtina S
Immunogenetics, 69, 653-659 (2017)
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