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F5882

Sigma-Aldrich

N-(3-[2-Furyl]acryloyl)-Ala-Lys

powder

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About This Item

Empirical Formula (Hill Notation):
C16H23N3O5
CAS Number:
76079-03-3
Molecular Weight:
337.37
MDL number:
MFCD00036815
UNSPSC Code:
12352204
PubChem Substance ID:
24894896
NACRES:
NA.32

Assay

≥98% (TLC)

Quality Level

200

form

powder

color

white to light yellow

solubility

water: 50 mg/mL

storage temp.

−20°C

SMILES string

C[C@H](NC(=O)\C=C\c1ccco1)C(=O)N[C@@H](CCCCN)C(O)=O

InChI

1S/C16H23N3O5/c1-11(18-14(20)8-7-12-5-4-10-24-12)15(21)19-13(16(22)23)6-2-3-9-17/h4-5,7-8,10-11,13H,2-3,6,9,17H2,1H3,(H,18,20)(H,19,21)(H,22,23)/b8-7+/t11-,13-/m0/s1

InChI key

BZUABSYGNBFITP-DDOQPMFUSA-N

Application

N-(3-[2-Furyl]acryloyl)-Ala-Lys has been used as a substrate in the carboxypeptidase B assay.

Substrates

Substrate for human plasma carboxypeptidase N.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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B G Grimwood et al.
Analytical biochemistry, 170(1), 264-268 (1988-04-01)
A new high performance liquid chromatographic method has been developed for the determination of carboxypeptidase N activity which quantitates the furylacryloyl-alanine released by enzymatic cleavage of furylacryloyl-alanyl-lysine or furylacryloyl-alanyl-arginine. A short isocratic gradient elutes the substrate and product in less
Alejandra P Frasch et al.
Molecular and biochemical parasitology, 184(2), 63-70 (2012-05-12)
Metallocarboxypeptidases (MCP) of the M32 family of peptidases have been identified in a number of prokaryotic organisms but they are absent from eukaryotic genomes with the remarkable exception of those of trypanosomatids. The genome of Trypanosoma brucei, the causative agent
An improved spectrophotometric assay for human plasma carboxypeptidase N1.
T H Plummer et al.
Analytical biochemistry, 108(2), 348-353 (1980-11-01)

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