Enalapril is an angiotensin-converting enzyme inhibitor. It is used to treat heart failure and high blood pressure.[1]
Application
Enalapril maleate salt has been used:
to reduce albumin excretion rate (AER) and glomerular lesions[2]
to examine the effects of enalapril pre-treatment on myocardial injury[3]
to investigate its efficacious doses and schedules for mitigation of radiation lung injury[4]
Biochem/physiol Actions
A long-acting angiotensin-converting enzyme inhibitor.
Features and Benefits
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Puromycin aminonucleoside (PA) can induce nephrotic syndrome in rats, and proteinuria is an important mediator of tubulointerstitial injury in glomerulopathy. We assumed that glomerular proteinuria may affect tubular function, such as urinary concentration, and investigated whether a urinary concentration defect
Diabetic nephropathy is associated with endothelial dysfunction and oxidative stress, in which the nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO-sGC-cGMP) signaling pathway is impaired. We hypothesize that sGC stimulator Compound 1 can enhance NO signaling, reduce proteinuria in a diabetic
Enalapril
Todd PA and Heel RC
Drugs, 31(3), 198-248 (1986)
Enalapril protects against myocardial ischemia/reperfusion injury in a swine model of cardiac arrest and resuscitation
Wang G, et al.
International Journal of Molecular Sciences, 38(5), 1463-1473 (2016)
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