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E0502

Sigma-Aldrich

Elastin–Congo red

elastase substrate

Synonym(s):

Elastin Congo red

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About This Item

MDL number:
MFCD00131000
UNSPSC Code:
12352204
NACRES:
NA.32

Quality Level

200

form

powder

storage temp.

2-8°C

General description

Elastin−Congo red is a substrate-dye conjugate and is used in agar medium to probe elastase activity. The presence of elastase functionality leads to cleavage of the dye from the elastin substrate.

Application

Elastin−Congo red has been used as a substrate for neutrophil elastase, salivary elastase and P. aeruginosa.

Other Notes

Elastin impregnated with Congo red dye.

Substrates

Substrate for the estimation of elastase.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H350,H361d

Hazard Classifications

Carc. 1B - Repr. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Development of an agar diffusion method to measure elastase inhibition activity using Elastin-Congo red
Jung KH and Kim HJ
Journal of microbiology and biotechnology, 16(8), 1320-1324 (2006)
Salivary immunity in elderly individuals presented with Candida-related denture stomatitis
Gasparoto T, et al.
Gerodontology, 29(2), e331-e339 (2012)
Faizan Abul Qais et al.
ACS omega, 6(29), 18823-18835 (2021-08-03)
Quorum sensing (QS) and biofilm inhibition are recognized as the novel drug targets for the broad-spectrum anti-infective strategy to combat the infections caused by drug-resistant bacterial pathogens. Many compounds from medicinal plants have been found to demonstrate anti-infective activity. However
AiiM lactonase strongly reduces quorum sensing controlled virulence factors in clinical strains of Pseudomonas aeruginosa isolated from burned patients
Lopez-Jacome LE, et al.
Frontiers in Microbiology, 10, 2657-2657 (2019)
Activation pattern of neutrophils from blood of elderly individuals with Candida-related denture stomatitis
Gasparoto TH, et al.
European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology, 31(6), 1271-1277 (2012)
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Elastase Function and Importance

Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.

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