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Robenidine hydrochloride

VETRANAL®, analytical standard

Synonym(s):

1,3-Bis[(4-chlorobenzylidene)amino]guanidine monohydrochloride

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About This Item

Empirical Formula (Hill Notation):
C15H13Cl2N5 · HCl
CAS Number:
Molecular Weight:
370.66
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

Cl[H].Clc1ccc(cc1)\C=N\NC(=N)N\N=C\c2ccc(Cl)cc2

InChI

1S/C15H13Cl2N5.ClH/c16-13-5-1-11(2-6-13)9-19-21-15(18)22-20-10-12-3-7-14(17)8-4-12;/h1-10H,(H3,18,21,22);1H/b19-9+,20-10+;

InChI key

LTWIBTYLSRDGHP-HCURTGQUSA-N

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General description

Robenidine hydrochloride is a coccidiostat and antibiotic, used in controlling coccidiosis.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Robenidine hydrochloride has been used as a reference standard in the determination of robenidine hydrochloride in eggs using online solid-phase extraction with liquid chromatography coupled with tandem mass spectrometry (SPE-LC-MS/MS).

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

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Pictograms

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Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Binh Nguyen et al.
Journal of the American Chemical Society, 124(46), 13680-13681 (2002-11-15)
A combination of biophysical techniques has been used to characterize the interaction of an antitrypanosomal agent, CGP 40215A, with DNA. The results from a broad array of methods (DNase I footprinting, surface plasmon resonance, X-ray crystallography, and molecular dynamics) indicate
O Heby et al.
Amino acids, 33(2), 359-366 (2007-07-05)
Trypanosomatids depend on spermidine for growth and survival. Consequently, enzymes involved in spermidine synthesis and utilization, i.e. arginase, ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase (AdoMetDC), spermidine synthase, trypanothione synthetase (TryS), and trypanothione reductase (TryR), are promising targets for drug development. The
Binh Nguyen et al.
Biophysical journal, 86(2), 1028-1041 (2004-01-30)
Many dicationic amidine compounds bind in the DNA minor groove and have excellent biological activity against a range of infectious diseases. Para-substituted aromatic diamidines such as furamidine, which is currently being tested against trypanosomiasis in humans, and berenil, which is
Anticoccidial drugs for preventive therapy in intensively reared pheasants.
Norton, CC and Wise, DR
The Veterinary Record, 109(25-26), 554-556 (1981)
R Mukhopadhyay et al.
Pharmacological research, 33(1), 67-70 (1996-01-01)
CGP 40215A, specific S-adenosylmethionine decarboxylase (AdoMetDC) inhibitor was found to inhibit the growth of Leishmania donovani promastigotes (strain UR6) in a dose-dependent manner with an IC50 of 18 microM. The growth inhibition was reversed with 100 microM of spermidine and

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