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C-022

Supelco

Chlordiazepoxide solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C16H14ClN3O
CAS Number:
58-25-3
Molecular Weight:
299.75
EC Number:
200-659-6
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

SNAP-N-SPIKE®, SNAP-N-SHOOT®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

CNC1=C[N+]([O-])=C(c2ccccc2)c3cc(Cl)ccc3N1

InChI

1S/C16H14ClN3O/c1-18-15-10-20(21)16(11-5-3-2-4-6-11)13-9-12(17)7-8-14(13)19-15/h2-10,18-19H,1H3

InChI key

VVMUANXXDBQGMO-UHFFFAOYSA-N

General description

Chlordiazepoxide is a benzodiazepine sold under trade names such as Librax® or Klopoxid for short-term treatment of anxiety or management of acute alcohol withdrawal syndrome. This certified solution standard is suitable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications from forensic analysis and clinical toxicology to urine drug testing and pharmaceutical research.

Application


  • Chlordiazepoxide hydrochloride in psychopharmacology: This research chemical is primarily used to investigate the pharmacokinetics and metabolic pathways of benzodiazepines. Studies such as those by Shayesteh et al. have explored the dissociation constants of benzodiazepines, aiding in the development of more effective anxiolytic treatments with a focus on minimizing side effects (Shayesteh et al., 2015).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Librax is a registered trademark of Valeant Pharmaceuticals North America LLC
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Kiersten S Smith et al.
Neuropharmacology, 63(2), 250-258 (2012-04-03)
GABA(A) receptor modulating drugs such as benzodiazepines (BZs) have been used to treat anxiety disorders for over five decades. In order to determine whether the same or different GABA(A) receptor subtypes are necessary for the anxiolytic-like action of BZs in
Physiology. The perfect hypnotic?
Emmanuel Mignot
Science (New York, N.Y.), 340(6128), 36-38 (2013-04-06)
Padmanaban S Suresh et al.
Immunopharmacology and immunotoxicology, 34(4), 586-589 (2012-01-03)
Total and differential leucocyte count (TLC and DLC) in blood circulation influence humoral immune response and stress alters TLC and DLC by leucocyte misdistribution. Chlordiazepoxide, a widely used benzodiazepine anti-stress agent, is reported to reverse suppression of antibody response induced
Line V Kristensen et al.
Journal of neurochemistry, 121(3), 373-382 (2012-02-24)
Several metabolic neuroimaging studies have indicated that bipolar patients with mania exhibit alterations in metabolic activity, suggesting that perturbations in corticolimbic function contribute to the functional deficits associated with the disease. Because pharmacological stimulation of K(v)7 channel function has shown
Ramakrishna Nirogi et al.
Journal of pharmacological and toxicological methods, 65(1), 37-43 (2011-10-25)
Assessment of respiratory safety is one of the most important requirements for new chemical entity (ICH Guideline S7A). The aim of the present study was to compare and validate respiratory safety pharmacology models in conscious rats, to find out the
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