QBD10631

Bis-MAL-Lysine-dPEG^®₄-TFP ester

• Synonym(s): Polyethylene glycol
• Empirical Formula (Hill Notation): C₃₇H₄₅F₄N₅O₁₃
• Molecular Weight: 843.77
• MDL number: MFCD28385461
• UNSPSC Code: 12352108
• PubChem Substance ID: 329823944
• NACRES: NA.22

Properties

• Assay: >90%
• form: solid or viscous liquid
• reaction suitability: reagent type: cross-linking reagent; reactivity: thiol reactive
• polymer architecture: shape: linear; functionality: monofunctional
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: O=C(C(NC(CCN1C(C=CC1=O)=O)=O)CCCCNC(CCN2C(C=CC2=O)=O)=O)NCCOCCOCCOCCOCCC(OC3=C(C(F)=CC(F)=C3F)F)=O

Description

Features and Benefits

Bis-MAL-Lysine-dPEG^®₄-TFP ester is a unique crosslinker containing two maleimide groups, one on each amine of lysine, a 4-unit, single molecular weight dPEG^® spacer arm, and a 2,3,5,6-tetrafluorophenyl (TFP) ester. Each maleimide group reacts with a sulfhydryl group, and the TFP ester reacts with a free amine. The single molecular weight dPEG^® spacer is hydrophilic and non-immunogenic. This reagent can be used to modify or form conjugates with antibodies, antibody fragments, peptides, and small molecules.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable