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Sigma-Aldrich

1,3-Dinitropyrene

99%

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About This Item

Empirical Formula (Hill Notation):
C16H8N2O4
CAS Number:
75321-20-9
Molecular Weight:
292.25
MDL number:
MFCD00010493
UNSPSC Code:
12352100
PubChem Substance ID:
24857149
NACRES:
NA.22

Quality Level

100

Assay

99%

form

solid

solubility

DMSO: soluble 2 mg/mL, clear, yellow to orange

SMILES string

[O-][N+](=O)c1cc([N+]([O-])=O)c2ccc3cccc4ccc1c2c34

InChI

1S/C16H8N2O4/c19-17(20)13-8-14(18(21)22)12-7-5-10-3-1-2-9-4-6-11(13)16(12)15(9)10/h1-8H

InChI key

KTNUVDBUEAQUON-UHFFFAOYSA-N

Related Categories

General description

The carcinogenecity of 1,3-dinitropyrene was studied in newborn female rats.

Application

1,3-Dinitropyrene has been used in:
  • modification of the umu-assay (ISO 13829) to assess the cytotoxic potential of toxins
  • in vitro synthesis of 1,N6-etheno-2′-deoxyadenosine and 1,N2-etheno-2′-deoxyguanosine

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302 + H312 + H332

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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K Imaida et al.
Carcinogenesis, 16(12), 3027-3030 (1995-12-01)
The carcinogenicities of 1-nitropyrene (1-NP), 4-nitropyrene (4-NP), 1,3-dinitropyrene (1,3-DNP), 1,6-dinitropyrene (1,6-DNP), 1,8-dinitropyrene (1,8-DNP), 3-hydroxy-1-nitropyrene (3-OH-1-NP) and a mixture of 6- and 8-hydroxy-1-nitropyrene (6/8-OH-1-NP) were investigated in newborn female rats. Newborn female CD rats were treated s.c. eight times at weekly
T Shimada et al.
Cancer research, 50(7), 2036-2043 (1990-04-01)
NADPH-fortified human liver microsomes were examined with regard to ability to detoxicate several chemicals that do not require enzymatic oxidation to elicit a genotoxic response in a Salmonella typhimurium TA1535/pSK1002 system where umu response is used as an indicator of
L B Tee et al.
Carcinogenesis, 9(10), 1869-1874 (1988-10-01)
Dinitropyrenes are mutagenic and carcinogenic environmental pollutants commonly found in diesel exhaust and airborne particulates. In the present study, the ability of rabbit lung to metabolize 1,8-dinitro[4,5,9,10-3H]pyrene by both oxygen-dependent and oxygen-independent pathways has been investigated. Using lung 9000 g
R Crebelli et al.
Mutation research, 346(3), 167-172 (1995-03-01)
The effect of fuel composition on the mutagenicity of diesel engine emission was investigated. To this end, a fuel matrix comprising fuels with different contents of aromatic and naphthenic compounds was used. Extracts of the organic phase of raw exhausts
F Rafil et al.
Applied and environmental microbiology, 57(4), 962-968 (1991-04-01)
Human intestinal microbial flora were screened for their abilities to reduce nitroaromatic compounds by growing them on brain heart infusion agar plates containing 1-nitropyrene. Bacteria metabolizing 1-nitropyrene, detected by the appearance of clear zones around the colonies, were identified as
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