73035AST

Astec^® CHIRALDEX^™ G-TA Capillary GC Column

L × I.D. 50 m × 0.25 mm, d_f 0.12 μm

• Synonym(s): GC column, chiral, gamma-dextran
• UNSPSC Code: 41115710
• NACRES: SB.54

Properties

• material: fused silica
• description: GC capillary column
• packaging: pkg of 1 ea
• parameter: -10-180 °C temperature (isothermal or programmed)
• Beta value: 500
• df: 0.12 μm
• technique(s): gas chromatography (GC): suitable
• L × I.D.: 50 m × 0.25 mm
• matrix active group: non-bonded; 2,6-di-O-pentyl-3-trifluoroacetyl derivative of γ-cyclodextrin phase
• application(s): agriculture; chemicals and industrial polymers; cleaning products; clinical; cosmetics; environmental; flavors and fragrances; food and beverages; forensics and toxicology; life science and biopharma; personal care; pharmaceutical (small molecule)
• column type: capillary chiral
• separation technique: chiral

Description

General description

Astec^® CHIRALDEX G-TA is the first choice in the Group 1 CSPs (Surface Interactions, Complex Derivatives). This phase has been shown to be the most broadly-selective phase for the pharmaceutical industry, especially for the analysis of chiral intermediates and drug studies in various stages of clinical trials. Separations occur without the inclusion mechanism and are typically faster and more efficient than most chiral stationary phases. G-TA has also been used to separate parent drug enantiomers and their metabolites. G-TA has its highest selectivity for oxygen-containing analytes like alcohols, diols and polyols as the free alcohol and as an acyl derivative; amines as acyl derivatives; amino alcohols, halogens (Cl>Br>F), amino acids, hydroxy acids, lactones, furans and pyrans. It is also highly selective for halogenated compounds.

Application

• Enantioselective gas chromatographic analysis of aqueous samples by on-line derivatisation. Application to enzymatic reactions.: This study explores the use of the Astec CHIRALDEX G-TA Capillary GC Column for enantioselective gas chromatographic analysis. The method involves on-line derivatization, enabling the analysis of aqueous samples and applying this technique to enzymatic reactions. This innovative approach highlights the column′s capability in achieving high selectivity and sensitivity for chiral compounds in complex matrices (Mommers et al., 2008).

Chem/Phys Resistance

Temp. Limits:

• -10 °C to 180 °C isothermal and programmed

Other Notes

We offer a variety of chromatography accessories including analytical syringes

Legal Information

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany

CHIRALDEX is a trademark of Sigma-Aldrich Co. LLC