U3750

Uridine

≥99%

• Synonym(s): 1-β-D-Ribofuranosyluracil, Uracil-1-β-D-ribofuranoside
• Empirical Formula (Hill Notation): C₉H₁₂N₂O₆
• CAS Number: 58-96-8
• Molecular Weight: 244.20
• Beilstein: 754902
• EC Number: 200-407-5
• MDL number: MFCD00006526
• UNSPSC Code: 41106305
• PubChem Substance ID: 24900640
• NACRES: NA.51

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• Assay: ≥99%
• form: powder
• mp: 163-167 °C (lit.)
• solubility: H₂O: 50 mg/mL, clear, colorless
• SMILES string: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O
• InChI: 1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1
• InChI key: DRTQHJPVMGBUCF-XVFCMESISA-N
• Gene Information: mouse ... Uck1(22245)

Description

General description

Uridine is a uracil nucleoside, specific for RNA sequence. Uridine is present in blood, seminal fluid and cerebrospinal fluid. Uridine is synthesized in living organisms by de novo and salvage pathways.

Application

Uridine has been used:

• as a component of hippocampal neuron medium for culture of primary hippocampal neuron cells
• in uridine rescue experiments in mouse embryonic fibroblasts and human breast cancer cells
• in chase sequencing experiments

Biochem/physiol Actions

Uridine monophosphate is essential for protein glycosylation, polysaccharide biosynthesis and lipid metabolism. Oral administration of uridine is suggested for anisopoikilocytosis and epileptic encephalopathy disorders. Uridine has numerous biological functions like treating dry eye syndrome, regulating nervous system and favors reproduction. High levels of uridine are implicated in insulin resistance.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves