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SML3852

Sigma-Aldrich

Saroglitazar Magnesium

≥98% (HPLC)

Synonym(s):

(αS)-α-Ethoxy-4-[2-[2-methyl-5-[4-(methylthio)phenyl]-1H-pyrrol-1-yl]ethoxy]benzenepropanoic acid Magnesium, (s)-2-Ethoxy-3-(4-(2-(2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-1-yl)ethoxy)phenyl)propanoic acid Magnesium

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About This Item

Empirical Formula (Hill Notation):
C50H56MgN2O8S2
CAS Number:
Molecular Weight:
901.42
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

SMILES string

[Mg+2].S(C)c4ccc(cc4)c5[n](c(cc5)C)CCOc6ccc(cc6)C[C@H](OCC)C(=O)[O-].S(C)c1ccc(cc1)c2[n](c(cc2)C)CCOc3ccc(cc3)C[C@H](OCC)C(=O)[O-]

InChI

1S/2C25H29NO4S.Mg/c2*1-4-29-24(25(27)28)17-19-6-10-21(11-7-19)30-16-15-26-18(2)5-14-23(26)20-8-12-22(31-3)13-9-20;/h2*5-14,24H,4,15-17H2,1-3H3,(H,27,28);/q;;+2/p-2/t2*24-;/m00./s1

InChI key

UJYFZCVPOSZDMK-YPPDDXJESA-L

Biochem/physiol Actions

Potent and selective PPARα/γ agonist.

Saroglitazar is a potent and selective PPARα/γ (peroxisome proliferator-activated receptor) agonist that exhibits lipid-lowering and insulin-sensitizing effects. Saroglitazar is approved in India for the treatment of diabetes type 2 and dyslipidemia.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Saroglitazar reduces obesity and associated inflammatory consequences in murine adipose tissue
European Journal of Pharmacology, 822, 32-42 (2018)
Saroglitazar, a novel PPAR?/? agonist with predominant PPAR? activity, shows lipid-lowering and insulin-sensitizing effects in preclinical models
Pharmacology Research & Perspectives, 3(3) (2015)
Saroglitazar, a novel dual PPAR-?/? agonist, reverses high fat-low protein diet-induced metabolic and cognitive aberrations in C57BL/6J male mice
Life Sciences, 271, 119191-119191 (2021)

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