SML0486

Elacridar

≥98% (HPLC), powder, ABC transporters MDR-1 (P-gp) inhibitor

• Synonym(s): GF120918, GG918, GW0918, N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide
• Empirical Formula (Hill Notation): C₃₄H₃₃N₃O₅
• CAS Number: 143664-11-3
• Molecular Weight: 563.64
• MDL number: MFCD00912604
• UNSPSC Code: 12161501
• PubChem Substance ID: 329825437
• NACRES: NA.77

Properties

• product name: Elacridar, ≥98% (HPLC)
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL (clear solution, warmed)
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: COc1cccc2C(=O)c3cccc(C(=O)Nc4ccc(CCN5CCc6cc(OC)c(OC)cc6C5)cc4)c3Nc12
• InChI: 1S/C34H33N3O5/c1-40-28-9-5-7-26-32(28)36-31-25(33(26)38)6-4-8-27(31)34(39)35-24-12-10-21(11-13-24)14-16-37-17-15-22-18-29(41-2)30(42-3)19-23(22)20-37/h4-13,18-19H,14-17,20H2,1-3H3,(H,35,39)(H,36,38)
• InChI key: OSFCMRGOZNQUSW-UHFFFAOYSA-N

Description

Application

Elacridar has been used:

• as a chemical to decipher the link between autophagy and the mechanism of resistance to sunitinib
• as an ATP-binding cassette sub-family B member 1 inhibitor to study its effects on the NSC23766 cytotoxicity
• to treat rhodamine 123 (Rh123) labeled cells to set sorting gates in fluorescence-activated cell sorting (FACS)

Biochem/physiol Actions

GF120918 (Elacridar) is a very potent inhibitor of the ABC transporters MDR-1 (P-gp) and BCRP. GF120918 increases the bioavailability of cytotoxic anti-tumor drugs, and also leads to increased levels of anti-HIV drugs in the brain and CNS.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable