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About This Item
Empirical Formula (Hill Notation):
C138H229N43O38S1
Molecular Weight:
3130.63
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
Assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥75%
storage condition
protect from light
storage temp.
−20°C
Amino Acid Sequence
Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Met-Val-Lys-Ser-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2
Application
β-Calcitonin gene related peptide (β-CGRP) regulates cardiovascular homeostasis and nociception via G-coupled protein receptor (GCPR) calcitonin receptor-like receptor (CALCRL).
CGRP II 8-37 is used as a CGRP receptor antagonist.
CGRP II 8-37 is used as a CGRP receptor antagonist.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Joseph J Lynch et al.
European journal of pharmacology, 623(1-3), 96-102 (2009-09-22)
The triptans, serotonin 5-HT(1B/1D) receptor agonists exemplified by sumatriptan, are a mainstay migraine therapy but have class labeling contraindicating their use in patients with coronary artery disease. Triptans constrict human coronary artery in vitro, and there are case reports of
Toomas Talme et al.
Journal of neuroimmunology, 196(1-2), 60-66 (2008-04-22)
CGRP significantly stimulated migration of non-activated and anti-CD3 activated T lymphocytes into a collagen matrix when present inside the collagen, whereas somatostatin-14, NPY, substance P, VIP, beta-endorphin and metenkephalin had no or little effect. The CGRP antagonist CGRP 8-37 abrogated
I-Ching Hou et al.
Peptides, 30(12), 2228-2232 (2009-09-02)
We found that beta-lactotensin (His-Ile-Arg-Leu), which has been isolated as an ileum-contracting peptide from chymotrypsin digest of bovine beta-lactoglobulin, dose-dependently suppresses food intake after intracerebroventricular (i.c.v.) or intraperitoneal administration at a dose of 40 nmol/mouse or 100mg/kg, respectively, in fasted
Jean-Olivier Zirimwabagabo et al.
Journal of medicinal chemistry, 64(6), 3299-3319 (2021-03-06)
Class B G-protein-coupled receptors (GPCRs) remain an underexploited target for drug development. The calcitonin receptor (CTR) family is particularly challenging, as its receptors are heteromers comprising two distinct components: the calcitonin receptor-like receptor (CLR) or calcitonin receptor (CTR) together with
Vince T Nguyen et al.
Peptides, 33(1), 77-82 (2011-11-24)
Cardiac epinephrine and calcitonin gene-related peptide (CGRP) are produced by intrinsic cardiac adrenergic cells (ICA cells) residing in human and animal hearts. ICA cells are neuroparicine cells expressing δ-opioid receptors (DOR). We hypothesized that δ-opioid stimulation of ICA cells enhances
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