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S9512

Sigma-Aldrich

Succinic acid

greener alternative

BioReagent, BioRenewable, suitable for cell culture, suitable for insect cell culture

Synonym(s):

Butanedioic acid

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About This Item

Linear Formula:
HOOCCH2CH2COOH
CAS Number:
110-15-6
Molecular Weight:
118.09
Beilstein:
1754069
EC Number:
203-740-4
MDL number:
MFCD00002789
UNSPSC Code:
12352207
PubChem Substance ID:
24899842
NACRES:
NA.71

product line

BioReagent

Assay

≥99.0% ( with NaOH, titration)

form

powder

greener alternative product characteristics

Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

technique(s)

cell culture | insect: suitable
cell culture | mammalian: suitable

bp

235 °C (lit.)

mp

184-186 °C (lit.)

solubility

water: 100 mg/mL, clear, colorless

density

1.564 g/cm3 at 15 °C

greener alternative category

Aligned,

SMILES string

OC(=O)CCC(O)=O

InChI

1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)

InChI key

KDYFGRWQOYBRFD-UHFFFAOYSA-N

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General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product is biobased and thus aligns with "Use of Renewable Feedstocks". Click here for more information.

Application

Use as a TCA (Krebs cycle) supplement in insect cell culture applications.

Other Notes

Succinic Acid: A New Platform Chemical for Biobased Polymers from Renewable Resources

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H318

Precautionary Statements

P280 - P305 + P351 + P338

Hazard Classifications

Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sodium succinate dibasic hexahydrate ReagentPlus®, ≥99%

Sigma-Aldrich

S2378

Sodium succinate dibasic hexahydrate

Succinic acid United States Pharmacopeia (USP) Reference Standard

USP

1623411

Succinic acid

Muhammad Fariz Ali et al.
Pathogens (Basel, Switzerland), 9(9) (2020-09-10)
To gain insight into how pathogens adapt to new hosts, Cryptococcus neoformans (H99W) was serially passaged in Galleria mellonella. The phenotypic characteristics of the passaged strain (P15) and H99W were evaluated. P15 grew faster in hemolymph than H99W, in vitro
Corey Osto et al.
Current protocols in cell biology, 89(1), e116-e116 (2020-12-16)
Measuring oxygen consumption allows for the role of mitochondrial function in biological phenomena and mitochondrial diseases to be determined. Although respirometry has become a common approach in disease research, current methods are limited by the necessity to process and measure
Monika Bambouskova et al.
Cell reports, 34(10), 108756-108756 (2021-03-11)
Itaconate is a unique regulatory metabolite that is induced upon Toll-like receptor (TLR) stimulation in myeloid cells. Here, we demonstrate major inflammatory tolerance and cell death phenotypes associated with itaconate production in activated macrophages. We show that endogenous itaconate is
José Manuel Otero et al.
PloS one, 8(1), e54144-e54144 (2013-01-26)
Saccharomyces cerevisiae is the most well characterized eukaryote, the preferred microbial cell factory for the largest industrial biotechnology product (bioethanol), and a robust commerically compatible scaffold to be exploitted for diverse chemical production. Succinic acid is a highly sought after
G M Tannahill et al.
Nature, 496(7444), 238-242 (2013-03-29)
Macrophages activated by the Gram-negative bacterial product lipopolysaccharide switch their core metabolism from oxidative phosphorylation to glycolysis. Here we show that inhibition of glycolysis with 2-deoxyglucose suppresses lipopolysaccharide-induced interleukin-1β but not tumour-necrosis factor-α in mouse macrophages. A comprehensive metabolic map
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