Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

H3916

Sigma-Aldrich

Hederagenin

≥97% (HPLC)

Synonym(s):

3,23-Dihydroxyolean-12-en-28-acid, Astrantiagenin E, Caulosapogenin, Hederagenic acid, Hederagenol

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C30H48O4
CAS Number:
465-99-6
Molecular Weight:
472.70
MDL number:
MFCD00017385
UNSPSC Code:
41116107
NACRES:
NA.25

Assay

≥97% (HPLC)

solubility

methanol: 1 mg/mL

storage temp.

2-8°C

SMILES string

O[C@H]1CC[C@@]2(C)[C@](CC[C@]3(C)[C@]2([H])CC=C4[C@@]3(C)CC[C@]5(C(O)=O)[C@@]4([H])CC(C)(C)CC5)([H])[C@]1(C)CO

InChI

1S/C30H48O4/c1-25(2)13-15-30(24(33)34)16-14-28(5)19(20(30)17-25)7-8-22-26(3)11-10-23(32)27(4,18-31)21(26)9-12-29(22,28)6/h7,20-23,31-32H,8-18H2,1-6H3,(H,33,34)/t20-,21+,22+,23-,26-,27-,28+,29+,30-/m0/s1

InChI key

PGOYMURMZNDHNS-MYPRUECHSA-N

Looking for similar products? Visit Product Comparison Guide

Application

Hederagenin (3,23-Dihydroxyolean-12-en-28-acid), a triterpenoid saponin, is used to study the properties of triterpenoid saponins as biopesticides that prevent fungal growth, bacterial growth, and viral plant diseases. Hederagenin may be used as a reference in assays to detect it in biological fluids.

Biochem/physiol Actions

Saponin. Anti-inflammatory.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 4

1 of 4

Maslinic acid ≥98% (HPLC)

Sigma-Aldrich

M6699

Maslinic acid

Oleanolic acid United States Pharmacopeia (USP) Reference Standard

USP

1478141

Oleanolic acid

Hederacoside C primary reference standard

00930585

Hederacoside C

β-Amyrin analytical standard

Supelco

09236

β-Amyrin

Jyoti Kalola et al.
Journal of AOAC International, 91(5), 1174-1178 (2008-11-05)
Fruit pericarp of Sapindus species are reported to contain glycosides with hederagenin as an aglycone. To free the aglycone from the glycosides, they need to be hydrolyzed, and the commonly used method is hydrolysis with either hydrochloric or sulfuric acid.
L Jayasinghe et al.
Phytochemistry, 40(3), 891-897 (1995-10-01)
Seven new saponins, all glycosides of hederagenin (3 beta,23- dihydroxyolean-12-en-28-oic acid), were isolated from the stem of Pometia eximia along with hederagenin and two known saponins. Their structures were established as 28-O-beta-D-apiosyl(1-->2)-beta-D-glucopyranosyl-, 3-O-alpha-L- arabinofuranosyl(1-->3)[alpha-L-rhamnopyranosyl (1-->2)]-beta-D- xylopyranosyl-, 3-O-beta-D-apiosyl(1-->3)[alpha-L-rhamnopyranosyl-(1-->2)-beta-D- glucopyranosyl-, 3-O-alpha-L-arabinofuranosyl(1-->3)[alpha-L-rhamnopyranosyl- (1-->2)]-beta-L-arabinopyranosyl-
Anti-inflammatory activities of hederagenin and crude saponin isolated from Sapindus mukorossi Gaertn.
K Takagi et al.
Chemical & pharmaceutical bulletin, 28(4), 1183-1188 (1980-01-01)
Xuemei Yang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(21), 1973-1979 (2011-06-18)
A rapid, sensitive and selective method was developed for the quantitative determination of hederagenin in rat plasma and cerebrospinal fluid (CSF) by ultra fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS). It has been successfully applied in a pharmacokinetic study of hederagenin
Zeng-Liang Jin et al.
Pharmacology, biochemistry, and behavior, 100(3), 431-439 (2011-10-19)
Fructus Akebiae is a traditional Chinese herbal extract that has been used for the treatment of depressive disorders in China. Previous studies demonstrated that Fructus Akebiae extracts (FAE) displayed a potent antidepressant-like activity in animal behavior tests and found that
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service