G6761

Glycine sodium salt hydrate

≥99% (HPLC)

• Linear Formula: H₂NCH₂CO₂Na · xH₂O
• CAS Number: 207300-76-3
• Molecular Weight: 97.05 (anhydrous basis)
• MDL number: MFCD00150683
• UNSPSC Code: 12352209
• eCl@ss: 32160406
• PubChem Substance ID: 24895270
• NACRES: NA.77

Properties

• biological source: synthetic (organic)
• Assay: ≥99% (HPLC)
• form: powder
• mol wt: 97.05 g/mol (anhydrous basis)
• technique(s): electrophoresis: suitable
• mp: 197-201 °C (lit.)
• SMILES string: [Na+].[H]O[H].NCC([O-])=O
• InChI: 1S/C2H5NO2.Na.H2O/c3-1-2(4)5;;/h1,3H2,(H,4,5);;1H2/q;+1;/p-1
• InChI key: CIJQGPVMMRXSQW-UHFFFAOYSA-M

Description

General description

Research area: Neuroscience

Glycine is a simple non-essential amino acidIt is synthesized from choline, threonine and serine. It serves as a precursor for porphyrins, purines, glutathione and creatine.

Application

Glycine sodium salt hydrate has been used as a component of buffer for homogenization of whole muscle for protein extraction and in electrophoresis buffer. It has also been used as a neurotransmitter in immunohistochemical staining of Zebrafish spinal cord sections.

Biochem/physiol Actions

Glycine serves as a neurotransmitter in the central nervous system. It aids in increasing the quality of sleep and neurological functions. It is essential for the regulation immune function, metabolism, growth and development. Glycine modulates intracellular Ca²⁺ levels and cytokines production. Studies have shown that glycine treatment effectively prevents organ transplantation failure by mitigating ischemia reperfusion injury caused by cold ischemic storage. Additionally, glycine treatment also enhances graft function during transplantation. A reduction in glycine levels is observed in obesity, type 2 diabetes (T2DM), and non-alcoholic fatty liver disease (NAFLDs). Glycine is degraded to serine by glycine serine hydroxymethyltransferase 1 in cytoplasm.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves