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Key Documents

COO/COA

EHU103811

MISSION^® esiRNA

Name: MISSION<SUP>®</SUP> esiRNA
Brand: SIGMA

targeting human BMPR2

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About This Item

UNSPSC Code:

41105324

NACRES:

NA.51

description

Quality Level

100

product line

MISSION^®

form

lyophilized powder

esiRNA cDNA target sequence

TTTCACTGGATGGTAATGTAACCTTAAAAGCATCATAATAGGTAAAGTCTAATATTAGTTCCCTTAACAAAATCCTAACTGTATACCAGAATTAGGTCACTGAAAGAACTTGATTTGAATTACGTTTAGACAAAAATGATTTAATTGTAAATTCTTAAAACTTTCTAAATGCATAATTGGCAAAAAAAAAAACCCACTGTTACCAGTGTAGGAAGTTACAAGAAGGCACATACTGAATGCTGAAGTATACATATGCTATTTCTCTTAAACCTCAGAGCAACCATATGAGCATTGTAATTAATATTCCCATTTTACAGATGAGGAAACTGAAGCTAAGAGAAGCTAAGTAATATGCCCAAGGTCCACATCTAGTAACAGACAAAGCTGGGATTTCAGTCTATGTCTGCCTCTCTCCACATCTCTTTCATCCATACCACACTGCCTACATGCC

Ensembl | human accession no.

ENSG00000204217

NCBI accession no.

NM_001204

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... BMPR2(659) , BMPR2(659)

Related Categories

MISSION® esiRNA

General description

MISSION esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Activation of yes-associated protein mediates sphingosine-1-phosphate-induced proliferation and migration of pulmonary artery smooth muscle cells and its potential mechanisms.

Wenhua Shi et al.

Journal of cellular physiology, 236(6), 4694-4708 (2020-12-08)

The aims of the present study were to examine the molecular mechanisms underlying sphingosine-1-phosphate (S1P)-induced rat pulmonary artery smooth muscle cells (PASMCs) proliferation/migration and to determine the effect of yes-associated protein (YAP) activation on S1P-induced PASMCs proliferation/migration and its potential

Tumor-Derived Factors and Reduced p53 Promote Endothelial Cell Centrosome Over-Duplication.

Zhixian Yu et al.

PloS one, 11(12), e0168334-e0168334 (2016-12-16)

Approximately 30% of tumor endothelial cells have over-duplicated (>2) centrosomes, which may contribute to abnormal vessel function and drug resistance. Elevated levels of vascular endothelial growth factor A induce excess centrosomes in endothelial cells, but how other features of the

BMP signaling is a therapeutic target in ovarian cancer.

Tomohiko Fukuda et al.

Cell death discovery, 6(1), 139-139 (2020-12-11)

BMP signaling has been found to have tumor-promoting as well as tumor-suppressing effects in different types of tumors. In this study, we investigated the effects of BMP signaling and of BMP inhibitors on ovarian cancer (OC) cells in vitro and

BMP-2 and -4 produced by vascular smooth muscle cells from atherosclerotic lesions induce monocyte chemotaxis through direct BMPRII activation.

Alex Yuri Simões Sato et al.

Atherosclerosis, 235(1), 45-55 (2014-05-13)

Monocytes and macrophages, together with vascular smooth muscle cells (VSMCs), play key roles at all stages of atherogenesis. There is also growing evidence that BMP signaling is involved in vascular diseases, including atherosclerosis. Here we evaluate the role played by

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