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D2396

Sigma-Aldrich

Dimenhydrinate

Synonym(s):

N-(2-Diphenylmethoxyethyl)-N,N-dimethylammonium 8-chlorotheophyllinate

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About This Item

Empirical Formula (Hill Notation):
C17H21NO · C7H7ClN4O2
CAS Number:
523-87-5
Molecular Weight:
469.96
EC Number:
208-350-8
MDL number:
MFCD00054265
UNSPSC Code:
41116107
PubChem Substance ID:
329798738
NACRES:
NA.77

form

powder

SMILES string

CN1C(=O)N(C)c2nc(Cl)[nH]c2C1=O.CN(C)CCOC(c3ccccc3)c4ccccc4

InChI

1S/C17H21NO.C7H7ClN4O2/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h3-12,17H,13-14H2,1-2H3;1-2H3,(H,9,10)

InChI key

NFLLKCVHYJRNRH-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

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General description

Dimenhydrinate is a salt of antihistamine drugs, such as diphenhydramine and 8-chlorotheophylline. It has antiemetic properties. Dimenhydrinate is used to treat nausea and vomiting during pregnancy.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Serge Gouin et al.
Pediatrics, 129(6), 1050-1055 (2012-05-16)
To evaluate the efficacy and safety of oral dimenhydrinate in the treatment of acute gastroenteritis. This was a randomized, double-blind, placebo-controlled trial conducted in the emergency department of a pediatric university-affiliated center. Children 1 to 12 years old who presented
Gerard Nobel et al.
Brain research bulletin, 82(3-4), 193-200 (2010-04-17)
Motion sickness (MS) exaggerates body cooling during cold-water immersion. The aim of the present study was to investigate whether such MS-induced predisposition to hypothermia is influenced by two anti-MS drugs: the histamine-receptor blocker dimenhydrinate (DMH) and the muscarine-receptor blocker scopolamine
Xiang Li et al.
The Journal of chemical physics, 133(14), 144304-144304 (2010-10-19)
The hydrated nucleoside anions, uridine(-)(H(2)O)(n=0-2), cytidine(-)(H(2)O)(n=0-2), and thymidine(-)(H(2)O)(n=0,1), have been prepared in beams and studied by anion photoelectron spectroscopy in order to investigate the effects of a microhydrated environment on parent nucleoside anions. Vertical detachment energies (VDEs) were measured for
Tawnya G Flick et al.
Analytical chemistry, 82(4), 1179-1182 (2010-01-23)
Accurate and rapid quantitation is advantageous to identify counterfeit and substandard pharmaceutical drugs. A standard-free electrospray ionization mass spectrometry method is used to directly determine the dosage in the prescription and over-the-counter drugs Tamiflu, Sudafed, and Dramamine. A tablet of
Kyle McKechnie et al.
Canadian journal of anaesthesia = Journal canadien d'anesthesie, 57(5), 453-457 (2010-03-06)
To describe a case of ventricular tachycardia after co-administration of ondansetron and dimenhydrinate to a child with occult congenital QT prolongation. A previously healthy 11-yr-old girl presented for surgical excision of a thyroglossal duct cyst under general anesthesia. Induction and
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