B2185

Bisoprolol hemifumarate salt

≥98% (HPLC), solid

• Synonym(s): 1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemifumarate salt
• Empirical Formula (Hill Notation): C₁₈H₃₁NO₄ · .5C₄H₄O₄
• CAS Number: 104344-23-2
• Molecular Weight: 383.48
• MDL number: MFCD00792743
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724414
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: solid
• color: white
• solubility: DMSO: >20 mg/mL
• originator: Teva
• SMILES string: OC(=O)\C=C\C(O)=O.CC(C)NCC(O)COc1ccc(COCCOC(C)C)cc1.CC(C)NCC(O)COc2ccc(COCCOC(C)C)cc2
• InChI: 1S/2C18H31NO4.C4H4O4/c2*1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h2*5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+
• InChI key: VMDFASMUILANOL-WXXKFALUSA-N
• Gene Information: human ... ADRB1(153)

Description

Application

Bisoprolol hemifumarate salt has been used as a β-adrenergic receptor (β-AR) antagonist in cardiac fibrosis mice model.

Biochem/physiol Actions

Bisoprolol hemifumarate is useful in oral formulations due to its high bioavailability. It also shows long elimination half-life.

Cardioselective β₁-adrenoceptor antagonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Teva. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Warning
• Hazard Statements: H302,H361fd,H373
• Precautionary Statements: P202 - P260 - P264 - P280 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 2 - STOT RE 2
• Target Organs: Heart
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves