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A9013

Sigma-Aldrich

1,5-Bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide

Synonym(s):

BW 284c51

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About This Item

Linear Formula:
C27H38N2OBr2
CAS Number:
402-40-4
Molecular Weight:
566.41
MDL number:
MFCD00063485
UNSPSC Code:
12352200
PubChem Substance ID:
24278243
NACRES:
NA.77

Assay

≥97% (HPLC)

Quality Level

200

form

powder

solubility

water: 19.60-20.40 mg/mL, clear, colorless

storage temp.

room temp

SMILES string

Br.C[N](C)(CC=C)c1ccc(CCC(=O)CCc2ccc(cc2)[N](C)(C)CC=C)cc1

InChI

1S/C27H38N2O.BrH/c1-7-21-28(3,4)25-15-9-23(10-16-25)13-19-27(30)20-14-24-11-17-26(18-12-24)29(5,6)22-8-2;/h7-12,15-18H,1-2,13-14,19-22H2,3-6H3;1H

InChI key

XBXRQUYORADPMX-UHFFFAOYSA-N

Gene Information

human ... ACHE(43)

Biochem/physiol Actions

Selective acetylcholinesterase inhibitor.

Features and Benefits

This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H300 + H310 + H330

Hazard Classifications

Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Kevin B Temeyer et al.
Veterinary parasitology, 172(1-2), 114-121 (2010-05-11)
Rhipicephalus (Boophilus) microplus cDNAs, BmAChE1, BmAChE2, and BmAChE3, were previously identified as presumptively encoding acetylcholinesterases (AChEs), but biochemical identity was confirmed only for recombinant BmAChE3. In the present study, four recombinant BmAChE1 constructs and single recombinant constructs of BmAChE2 and
Silvia Olivera-Bravo et al.
British journal of pharmacology, 144(1), 88-97 (2005-01-13)
This work was aimed to determine if 1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide (BW284c51), the most selective acetylcholinesterase inhibitor (AchEI), affects the nicotinic acetylcholine (Ach) receptor (AchR) function. Purified Torpedo nicotinic AchRs were injected into Xenopus laevis oocytes and BW284c51 effects on Ach- and
Marcia D Howard et al.
Toxicology, 238(2-3), 157-165 (2007-07-24)
Organophosphorus (OP) pesticides elicit acute toxicity by inhibiting acetylcholinesterase (AChE), the enzyme responsible for inactivating acetylcholine (ACh) at cholinergic synapses. A number of OP toxicants have also been reported to interact directly with muscarinic receptors, in particular the M(2) muscarinic
Eberhard Küster
Aquatic toxicology (Amsterdam, Netherlands), 75(1), 76-85 (2005-08-23)
Insecticides are a potential hazard for non-target organisms like fish particularly at run off events. The study of effects to embryos of the zebra fish Danio rerio is already an accepted tool in waste water monitoring, but effects of various
Noa Farchi et al.
Neuro-degenerative diseases, 4(2-3), 171-184 (2007-06-29)
Peripheral anionic site (PAS) blockade of acetylcholinesterase (AChE) notably affects neuronal activity and cyto-architecture, however, the mechanism(s) involved are incompletely understood. We wished to specify the PAS extracellular effects on specific AChE mRNA splice variants, delineate the consequent cellular remodeling
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