85580

Spermidine trihydrochloride

≥99.0% (AT)

• Synonym(s): N-(3-Aminopropyl)-1,4-butanediamine trihydrochloride
• Linear Formula: NH₂(CH₂)₃NH(CH₂)₄NH₂ · 3HCl
• CAS Number: 334-50-9
• Molecular Weight: 254.63
• Beilstein: 3552356
• EC Number: 206-379-0
• MDL number: MFCD00012918
• UNSPSC Code: 12352204
• PubChem Substance ID: 329769390
• NACRES: NA.77

Properties

• biological source: microbial; synthetic
• Assay: ≥99.0% (AT)
• form: powder
• mp: ~250 °C (dec.); 257-259 °C (lit.)
• solubility: H₂O: 0.1 g/mL, clear, colorless
• storage temp.: room temp
• SMILES string: Cl[H].Cl[H].Cl[H].NCCCCNCCCN
• InChI: 1S/C7H19N3.3ClH/c8-4-1-2-6-10-7-3-5-9;;;/h10H,1-9H2;3*1H
• InChI key: LCNBIHVSOPXFMR-UHFFFAOYSA-N

Description

General description

Spermidine is a polyamine and a trivalent organic cation.

Application

Spermidine trihydrochloride has been used as standard for the detection of biogenic amines using HPLC.

Biochem/physiol Actions

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T₄ polynucleotide kinase activity.

Spermidine modulates various cellular activities like cellular development and differentiation, stability of DNA and apoptosis.

Caution

Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319
• Precautionary Statements: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves