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338826

Sigma-Aldrich

Acetic acid

glacial, ≥99.99% trace metals basis

Synonym(s):

Glacial acetic acid

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About This Item

Linear Formula:
CH3CO2H
CAS Number:
64-19-7
Molecular Weight:
60.05
Beilstein:
506007
EC Number:
200-580-7
MDL number:
MFCD00036152
UNSPSC Code:
12352106
PubChem Substance ID:
329754692
NACRES:
NA.21

Agency

suitable for ASTM® 7969
suitable for ASTM® 7979
suitable for DIN 38407-43
suitable for EPA 1634
suitable for EPA 534
suitable for EPA 8328
suitable for EPA ACB B21-03
suitable for ISO 21675 2019
suitable for ISO 25101
suitable for ISO/CEN 15968-2011

Quality Level

100

vapor density

2.07 (vs air)

Assay

≥99.99% trace metals basis

form

liquid

autoignition temp.

800 °F

expl. lim.

16 %, 92 °F
4 %, 59 °F

technique(s)

HPLC: suitable

refractive index

n20/D 1.371 (lit.)

pH

2.5 (20 °C, 50 g/L)

bp

117-118 °C (lit.)

mp

16.2 °C (lit.)

density

1.04 g/mL at 25 °C (lit.)

SMILES string

[F2C(F2C)13F3C]C(O)=O

InChI

1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)

InChI key

QTBSBXVTEAMEQO-UHFFFAOYSA-N

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Application

Acetic acid can be used as a catalyst:
  • For the solvent-free one-pot condensation of indoles with aryl or heteroaryl aldehydes to synthesize di(indolyl)methanes.
  • In the Pictet-Spengler reaction of substituted tryptamines with cyclic ketones to synthesize tetrahydrospiro-Ͱ-carbolines.
  • To synthesize trisubstituted thiazoles via domino multicomponent reaction.

It can also be used as a:
  • solvent to synthesize aryl amine-functionalized 1,3,5-triazine derivatives via aryl amination of cyanuric chloride with aromatic amines.

Legal Information

ASTM is a registered trademark of American Society for Testing and Materials

Pictograms

FlameCorrosion
GHS02,GHS05

Signal Word

Danger

Hazard Statements

H226,H314

Hazard Classifications

Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1A

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

102.2 °F - closed cup

Flash Point(C)

39 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Glacial acetic acid United States Pharmacopeia (USP) Reference Standard

USP

1005706

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Glacial Acetic Acid Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1748

Glacial Acetic Acid

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