310468

Lithium chloride

ACS reagent, ≥99%

• Linear Formula: LiCl
• CAS Number: 7447-41-8
• Molecular Weight: 42.39
• EC Number: 231-212-3
• MDL number: MFCD00011078
• UNSPSC Code: 12352302
• PubChem Substance ID: 329753626
• NACRES: NA.21

Properties

• grade: ACS reagent
• Assay: ≥99%
• form: crystalline powder; powder, crystals or granules
• impurities: ≤0.008 meq/g Titr. base; ≤0.01% insolubles
• loss: ≤1.0% loss on drying
• pH: 6
• mp: 605 °C (lit.)
• anion traces: sulfate (SO₄^2-): ≤0.01%
• cation traces: Ba: ≤0.003%; Ca: ≤0.01%; Fe: ≤0.001%; K: ≤0.01%; Na: ≤0.20%; heavy metals: ≤0.002% (by ICP)
• SMILES string: [Li+].[Cl-]
• InChI: 1S/ClH.Li/h1H;/q;+1/p-1
• InChI key: KWGKDLIKAYFUFQ-UHFFFAOYSA-M

Description

General description

Lithium chloride (LiCl) is a lithium salt. It is used as a source of chloride nucleophile as well as a source of chloride ligand in chemical synthesis. LiCl is also used as a desiccant in drying air streams.

Application

Lithium chloride can be used as:      

• A source of chloride anion for the conversion of alcohols to alkyl chloride under Mitsunobu conditions.      
• An additive in the palladium-catalyzed coupling and carbonylative coupling reactions of organostannanes and vinyl triflates.      
• A reagent for the cleavage of protecting groups under mild conditions. It readily converts acetals and ketals to the corresponding carbonyl compounds.
• A reagent in the dehydrohalogenation of α-halocarbonyl compounds to α,β-unsaturated carbonyls compound in the presence of DMF.

LiCl is also used with other reagents:      

• LiCl:DIPEA (1:1 molar ratio) is used in Horner–Wadsworth–Emmons alkenation reaction.      
• LiCl:Hexamethylphosphoric triamide is used in decarboxylative alkylation and chloride displacement reactions.
• LiCl is used as an additive in solid-phase peptide synthesis because it increases resin swelling and improves the efficiencies of complex coupling steps.

Features and Benefits

• Easy to handle      
• Weak Lewis acid      
• Highly soluble in water

Other Notes

Go to Redi-Dri^™ Product Listing 746460

Legal Information

Redi-Dri is a trademark of Sigma-Aldrich Co. LLC

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302,H315,H319
• Precautionary Statements: P264 - P270 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable