Skip to Content
Merck
All Photos(1)

Key Documents

Y0000487

Leflunomide impurity A

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

4-(Trifluoromethyl)aniline, α,α,α-Trifluoro-p-toluidine, 4-Aminobenzotrifluoride

Sign Into View Organizational & Contract Pricing


About This Item

Linear Formula:
CF3C6H4NH2
CAS Number:
Molecular Weight:
161.12
Beilstein:
1564853
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

leflunomide

manufacturer/tradename

EDQM

refractive index

n20/D 1.483 (lit.)

bp

83 °C/12 mmHg (lit.)

density

1.283 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Nc1ccc(cc1)C(F)(F)F

InChI

1S/C7H6F3N/c8-7(9,10)5-1-3-6(11)4-2-5/h1-4H,11H2

InChI key

ODGIMMLDVSWADK-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Leflunomide impurity A EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3


Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

If you need assistance, please contact Customer Support.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Guiping Ouyang et al.
Molecules (Basel, Switzerland), 10(10), 1351-1357 (2007-11-17)
A facile synthesis of 3-methylthio-3-arylamino-2-cyanoacrylates from 3,3-dimethylthioacrylate and aromatic amines or amino pyridines has been achieved in moderate to high yields (64.0% ~ 93.5%) in 30 minutes at 50 degrees C under microwave irradiation. This method is very simple and
T Kunisawa
Journal of theoretical biology, 213(1), 9-19 (2001-11-16)
A simple method is presented for reconstructing phylogenetic trees on the basis of gene transposition. It is shown that differences in gene arrangements among genomes could allow us to determine whether a gene transposition event has occurred before or after
B A Maguire et al.
Biochimica et biophysica acta, 1353(2), 137-147 (1997-08-07)
The rpmB,G operon of Escherichia coli codes for proteins L28 and L33 of the larger (50S) ribosomal subunit. Strains with mutations in this operon can help define the roles of these proteins in ribosome synthesis and function. One such strain
B A Maguire et al.
Journal of bacteriology, 179(8), 2486-2493 (1997-04-01)
The rpmBG operon of Escherichia coli codes for ribosomal proteins L28 and L33. Two strains with mutations in the operon are AM81, whose ribosomes lack protein L28, and AM90, whose ribosomes are without protein L33. Neither strain showed major defects
J Seifert et al.
Toxicology, 83(1-3), 49-59 (1993-10-25)
Reactive isomeric 3- and 4-trifluoromethylanilines (3-,4-TFMA), and control aniline itself, induced the following effects on biosynthesis of DNA in the liver, kidney, thymus and spleen of rats: (a) The administration of 4-TFMA initially suppressed the utilization of labeled thymidine for

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service