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Y0000462

Torasemide for system suitability

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Torsemide, Demadex, N-[[(1-Methylethyl)amino]carbonyl]-4-[(3-methylphenyl)amino]-3-pyridinesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C16H20N4O3S
CAS Number:
56211-40-6
Molecular Weight:
348.42
MDL number:
MFCD00866166
UNSPSC Code:
41116107
PubChem Substance ID:
329830971
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

torasemide

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2

InChI

1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)

InChI key

NGBFQHCMQULJNZ-UHFFFAOYSA-N

Gene Information

human ... SLC12A1(6557)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Torasemide for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Torsemide is a loop diuretic of the pyridine-sulfonylurea class with antialdosteronergic properties and inhibitor of the Na+/K+/2Cl- carrier system.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H319,H361fd

Hazard Classifications

Eye Irrit. 2 - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

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[Treatment of nephritic edema by torasemide in children].
Qi Li et al.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 13(6), 520-521 (2011-06-16)
[Etiologies of nephrotic syndrome].
S Heeringa et al.
Praxis, 100(9), 505-514 (2011-04-29)
Agents with antialdosterone properties should be the preferred diuretics for reducing hypertension related atrial fibrillation.
Oscar M P Jolobe
European journal of internal medicine, 21(1), 55-55 (2010-02-04)
Cuixia Li et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 79(5), 1084-1090 (2011-06-11)
In pH 0.6-1.1 HCl-NaAc buffer solution, torasemide (TOR) reacted with TP to form a 3:1 ion-association complexes. As a result, not only the absorption spectra were changed, but also the intensities of resonance Rayleigh scattering (RRS), second-order scattering (SOS) and
Clinical therapeutics, 33(9), 1204-1213 (2011-09-13)
The pharmacologic modification of the synthesis and deposition of fibrillar collagen in the myocardium may have effects on the cardiac function, clinical status, and prognosis of patients with heart failure (HF). Serum procollagen type I carboxyterminal peptide (PICP) is a
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