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471216

Sigma-Aldrich

Diethylamine

≥99.5%

Synonym(s):

N,N-Diethylamine, N-ethyl-ethanamine, DEA, Diethamine, Diethyl amine

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About This Item

Linear Formula:
(C2H5)2NH
CAS Number:
Molecular Weight:
73.14
Beilstein:
605268
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.21

vapor density

2.5 (vs air)

Quality Level

vapor pressure

14.14 psi ( 55 °C)
180 mmHg ( 20 °C)
3.51 psi ( 20 °C)

Assay

≥99.5%

form

liquid

autoignition temp.

594 °F

expl. lim.

10.1 %

technique(s)

GC/MS: suitable

refractive index

n20/D 1.385 (lit.)

pH

13 (20 °C, 100 g/L)

bp

55 °C (lit.)

mp

−50 °C (lit.)

solubility

water: soluble

density

0.707 g/mL at 25 °C (lit.)

SMILES string

CCNCC

InChI

1S/C4H11N/c1-3-5-4-2/h5H,3-4H2,1-2H3

InChI key

HPNMFZURTQLUMO-UHFFFAOYSA-N

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General description

Diethylamine (DEA) is an organic base and a weak σ-donor ligand.

Application

Diethylamine has been used to constitute the extraction solvent mixture for the gas chromatography-mass spectrometric (GC-MS) analysis of melamine and related compounds. It has been also been used as a bond breaking agent in a novel ELISA technique to measure the avidity index (AI) of IgG-anti-PT (Immunoglobulin G-anti-pertussis toxin) antibodies.
It may be used as:
  • An organocatalyst for the preparation of β-phosphonomalononitriles and diethyl (2-amino-3- cyano-chromene-4-yl) phosphonic acid esters.
  • A ligand for the synthesis of (N-heterocyclic carbene)PdCl2(diethylamine) complexes.
  • A template for the preparation of thermally and hydrothermally stable SAPO-34 (silicoaluminophosphate) molecular sieves.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1A - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

-14.8 °F - closed cup

Flash Point(C)

-26 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Synthesis, characterization and catalytic properties of SAPO-34 synthesized using diethylamine as a template.
Liu G, et al.
Microporous and Mesoporous Materials : The Official Journal of the International Zeolite Association, 111(1), 143-149 (2008)
Inhibited Catalyst Activation in (N-Heterocyclic carbene) PdCl2 (diethylamine) Complexes by Intramolecular Hydrogen Bonding.
Chen MT, et al.
Organometallics, 30(24), 6770-6773 (2011)
Tongyao Wei et al.
STAR protocols, 2(3), 100777-100777 (2021-09-07)
Dissecting the function of proteins' post-translational modifications (PTMs) is seriously hindered by the difficulty in obtaining the homogeneous protein with the PTMs of interest. Chemical protein synthesis offers a great potential to overcome this limitation. Here, a detailed protocol is
A practical and highly efficient protocol for multicomponent synthesis of β-phosphonomalononitriles and 2-amino-4H-chromen-4-yl phosphonates using diethylamine as a novel organocatalyst.
Kulkarni MA, et al.
Comptes Rendus Chimie, 15(9), 745-752 (2012)
Alex-Mikael Barkoff et al.
Vaccine, 30(48), 6897-6902 (2012-09-18)
Pertussis toxin (PT) is a specific virulence factor of Bordetella pertussis and it is included in all acellular pertussis vaccines (aP). Although immunity after infection seems to persist longer than that after vaccination, the exact mechanism(s) is not known. Primary

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