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318604

Sigma-Aldrich

Ammonium chloride-ammonium hydroxide buffer solution

in H2O

Synonym(s):

Ammonium Buffer Solution

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About This Item

MDL number:
MFCD00134124
UNSPSC Code:
12161705
PubChem Substance ID:
329753929
NACRES:
NA.21

form

liquid

Quality Level

100

composition

NH4Cl, 1 wt. %
NH4OH, 4 wt. % (pH 10 to 11)

concentration

in H2O

pH

10-11

density

0.99 g/mL at 25 °C

SMILES string

N.N.O.Cl

InChI

1S/ClH.2H3N.H2O/h1H;2*1H3;1H2

InChI key

XEXFVRMLYUDDJY-UHFFFAOYSA-N

Application

Ammonium chloride-ammonium hydroxide buffer solution may be used to crystallize proteins.

Biochem/physiol Actions

Ammonium chloride is the salt component of ammonium chloride-ammonium hydroxide buffer system that completely inhibits the BVDV infection of MDBK cells when present at a concentration of 50 mM . Viruses treated with ammonium chloride (NH4Cl) results in loss of infectivity because it neutralizes the pH of endosome. Hence, viruses with low pH-dependent fusion activity became incapable to fuse their envelope with endosomal membrane.

Pictograms

CorrosionEnvironment
GHS05,GHS09

Signal Word

Danger

Hazard Statements

H315,H318,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000328674
0000232874
0000216629
0000216631
0000285556

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Ammonium chloride ACS reagent, ≥99.5%

Sigma-Aldrich

213330

Ammonium chloride

Thomas Krey et al.
Journal of virology, 79(7), 4191-4200 (2005-03-16)
The route of internalization of the pestivirus bovine viral diarrhea virus (BVDV) was studied by using different chemical and biophysical inhibitors of endocytosis. Expression of the dominant-negative mutant Dyn(K44A) of the GTPase dynamin in MDBK cells, as well as the
A Takada et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(26), 14764-14769 (1998-02-07)
Ebola virus causes hemorrhagic fever in humans and nonhuman primates, resulting in mortality rates of up to 90%. Studies of this virus have been hampered by its extraordinary pathogenicity, which requires biosafety level 4 containment. To circumvent this problem, we
Julia S Brunner et al.
Nature communications, 11(1), 431-431 (2020-01-24)
Multinucleated giant cells (MGCs) are implicated in many diseases including schistosomiasis, sarcoidosis and arthritis. MGC generation is energy intensive to enforce membrane fusion and cytoplasmic expansion. Using receptor activator of nuclear factor kappa-Β ligand (RANKL) induced osteoclastogenesis to model MGC

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