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ACOA-RO

Roche

Acetyl-Coenzyme A

85% (Enzymatic and Absorbance), 2% (lithium)

Synonym(s):

Acetyl-Coenzyme A, acetyl-coa

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About This Item

UNSPSC Code:
12352204

description

Chemical Formula: C23H35N7O17P3SLi3

Quality Level

100

Assay

85% (Enzymatic and Absorbance)

form

solid

mol wt

Mr 809.6 (acetyl-CoA)
Mr 827.4 (acetyl-CoA-Li3)

packaging

pkg of 010 mg (10101893001)
pkg of 200 mg (11585371001)
pkg of 050 mg (10101907001)

manufacturer/tradename

Roche

concentration

2% (lithium)

storage temp.

2-8°C

General description

Acetyl-Coenzyme A, trilithium salt

Application

Acetyl-Coenzyme A is used to assay CAT enzyme activity in cell extracts using radioisotopes. CAT enzyme activity in cell extracts catalyzes the transfer of acetyl groups from acetylcoenzyme A to chloramphenicol. A number of assays have been developed to measure CAT activity in cell extracts. Acetyl-Coenzyme A has also been used to determine citrate synthase activity.

Biochem/physiol Actions

Acetyl-Coenzyme A (Ac-CoA) is the end product of glycolysis and takes part in the Ac-CoA pathway, which is a metabolic pathway for carbon compounds. Ac-CoA is important in cholesterol synthesis. It also takes part in fatty acid biosynthesis and catabolism of polyamines like spermine and spermidine. A low level of Ac-CoA leads to a loss in glial cell and neuronal function. Ketone bodies and triglycerides give rise to Ac-CoA on hydrolysis and this indirectly leads to increased histone acetylation.

Preparation Note

Working solution: Optimal solvent: water or aqueous solution with a weak acidic pH (4 to 5).
Storage conditions (working solution): -15 to -25 °C
50 mg/ml in phosphate buffer, pH 7, is stable for 3 weeks at -15 to -25 °C. Unfrozen solutions should be immediately used.

Other Notes

For life science research only. Not for use in diagnostic procedures.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Biochemistry null
L Lu et al.
The Journal of biological chemistry, 271(31), 18920-18924 (1996-08-02)
Polyamine catabolism is rate limited by spermidine/spermine N1-acetyltransferase (SSAT). Although the amino acid sequence of SSAT is known, the substrate binding and catalytic sites are not. The goal of this study was to define the region responsible for acetyl coenzyme
Short-term variation of nutritive and metabolic parameters in Temora longicornis females (Crustacea, Copepoda) as a response to diet shift and starvation
Tobias Kreibich
Helgoland Marine Research , 62(3), 241-249 (2008)
Jean-Pierre Montmayeur and Johannes le Coutre
Fat Detection-Taste, Texture, and Post Ingestive Effects null
Morten Scheibye-Knudsen et al.
Cell metabolism, 20(5), 840-855 (2014-12-03)
Cockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodegeneration caused by mutations in genes encoding the DNA repair proteins CS group A or B (CSA or CSB). Since dietary interventions can alter neurodegenerative processes, Csb(m/m) mice were
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