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19-123-M

Sigma-Aldrich

Staurosporine

Staurosporine Streptomyces is a potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases.

Synonym(s):

PKC inhibitor, protein kinase C inhibitor

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About This Item

UNSPSC Code:
12352200
eCl@ss:
32160405
NACRES:
NA.41

Quality Level

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

General description

Suitable for use as a potent inhibitor of PKC and other protein kinases in vitro and in cultured cells.

Application

Staurosporine has been used as a protein kinase inhibitor to study the ubiquitin-protein ligase E3 component N-recognin 5 (UBR5)-mediated CDC73 regulation at the protein level. Staurosporine has been used to induce apoptosis in CHO-K1 cell lines, followed by cell imaging and extraction of cell lysate for further analysis.

Biochem/physiol Actions

Staurosporine, a broad-spectrum protein kinase inhibitor, belongs to the indolocarbazole family. It is referred to as a prototypical ATP-competitive kinase inhibitor. Staurosporine is effective against various kinds of cancers. It is commonly used for inducing apoptosis in different types of cells.

Quality

Routinely evaluated by Protein Kinase Inhibition Assay

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Health hazard

Signal Word

Warning

Hazard Statements

Hazard Classifications

Aquatic Chronic 4 - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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