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700159P

Avanti

Hyocholic acid

Avanti Research™ - A Croda Brand

Synonym(s):

3α,6α,7α-trihydroxy-5β-cholanic acid

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About This Item

Empirical Formula (Hill Notation):
C24H40 O5
CAS Number:
547-75-1
Molecular Weight:
408.57
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 5 mg (700159P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

bile acids

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C24H40O5/c1-13(4-7-19(26)27)15-5-6-16-20-17(9-11-23(15,16)2)24(3)10-8-14(25)12-18(24)21(28)22(20)29/h13-18,20-22,25,28-29H,4-12H2,1-3H3,(H,26,27)/t13-,14-,15-,16+,17+,18+,20+,21-,22+,23-,24-/m1/s1

InChI key

DKPMWHFRUGMUKF-KWXDGCAGSA-N

General description

Hyocholic acid, also called the 3α,6α,7α-trihydroxy-5β-cholanoic acid, is synthesized by the 6α-hydroxylation of chenodeoxycholic acid. It is a primary trihydroxylated bile acid associated with pigs. It is a minor bile acid in humans. Hyocholic acid is also synthesized from α-muricholic acid (MCA) in liver by the action of cytochrome P450 3A4 (CYP3A4).

Biochem/physiol Actions

Hyocholic acid levels are elevated in plasma and urine samples of patients with cholestatic liver disease and in hepatic cirrhosis.

Packaging

5 mL Amber Glass Screw Cap Vial (700159P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

also commonly purchased with this product

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Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hyodeoxycholic acid methyl ester ≥98%

Sigma-Aldrich

H2517

Hyodeoxycholic acid methyl ester

Tammy L Kindel et al.
Surgical endoscopy, 32(2), 805-812 (2017-08-06)
Bile acids (BAs) are post-prandial hormones that play an important role in glucose and lipid homeostasis as well as energy expenditure. Total and glycine-amidated BAs increase after sleeve gastrectomy (SG) and correlate to improved metabolic disease. No specific bile acid
K Lundell et al.
The Journal of biological chemistry, 276(13), 9606-9612 (2000-12-23)
A cytochrome P450 expressed in pig liver was cloned by polymerase chain reaction using oligonucleotide primers based on amino acid sequences of the purified taurochenodeoxycholic acid 6alpha-hydroxylase. This enzyme catalyzes a 6alpha-hydroxylation of chenodeoxycholic acid, and the product hyocholic acid

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