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100403X

Avanti

GPC-d9

Avanti Research™ - A Croda Brand

Synonym(s):

(d9)choline alfoscerate
α-GPC(d9); α-GPC(d9)

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About This Item

Empirical Formula (Hill Notation):
C8H11D9NO6P
CAS Number:
2260669-07-4
Molecular Weight:
266.28
UNSPSC Code:
51321705
NACRES:
NA.25

description

L-α-glycerophosphoryl(choline-d9), water:ethanol (9:1)

Assay

>99% phosphorus (P) basis (qNMR)

form

solution

packaging

pkg of 1 × 1 mL (100403X-100ug)

manufacturer/tradename

Avanti Research™ - A Croda Brand

concentration

0.1 mg/mL (100403X-100ug)

shipped in

dry ice

storage temp.

−20°C

General description

GPC rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter.
Glycerophosphocholine (GPC), is a water-soluble deacylated phosphatidylcholine derivative. It is majorly generated from choline based phospholipids associated with membranes. GPC is widely distributed in human blood and saliva. L-α-glycerophosphoryl(choline-d9) (GPC-d9) is the deuterium-labeled form of GPC.

Application

GPC-d9 has been used as an internal standard in ultra-performance liquid chromatograph coupled to a SCIEX 4500QT mass spectrometer (UPLC-MS/MS) for the quantification of choline compounds from whole milk samples.

Biochem/physiol Actions

Glycerophosphocholine (GPC) protects mitochondrial respiratory complex I during oxidative stress associated with liver ischemia-reperfusion. GPC is an ergogenic supplement that improves muscle force production. The deuterium-labeled glycerophosphocholine is employed as an internal standard for human milk choline quantification using liquid chromatography-tandem mass spectrometry.

Packaging

5 mL Clear Glass Sealed Ampule (100403X-100ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Evaluation of the effects of two doses of alpha glycerylphosphorylcholine on physical and psychomotor performance
Marcus L, et al.
Journal of the International Society of Sports Nutrition, 14(1), 39-39 (2017)
Targeting mitochondrial dysfunction with L-alpha glycerylphosphorylcholine
Strifler G, et al.
PLoS ONE, 11(11) (2016)
Targeting mitochondrial dysfunction with L-alpha glycerylphosphorylcholine
Strifler G, et al.
Testing, 11(11) (2016)
Total Water-Soluble Choline Concentration Does Not Differ in Milk from Vegan, Vegetarian, and Nonvegetarian Lactating Women
Perrin MT, et al.
The Journal of Nutrition, 11(12), 3024-3024 (2019)
Variability of Water-Soluble Forms of Choline Concentrations in Human Milk during Storage, after Pasteurization, and among Women
Moukarzel S, et al.
Nutrients, 11(12), 3024-3024 (2019)
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