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Key Documents

920037

Sigma-Aldrich

Low endotoxin gelatin from bovine bone

gel strength 300 (bloom)

Synonym(s):

X-PURE® 10B HBHV

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About This Item

CAS Number:
UNSPSC Code:
12352202
NACRES:
NA.23

form

powder

Quality Level

impurities

≤10 EU/g Endotoxin

color

white to off-white

storage temp.

2-8°C

Application

This low endotoxin gelatin is an alkaline gelatin extacted from bovine bones and specifically designed for applications requiring intensely purified biomateirals.

Gelatin is widely used for tissue engineering and 3D bioprinting. Gelatin is derived from natural extracellular matrix (ECM) components. Due to its low cost, abundance, and retention of natural cell binding motifs, gelatin has become a highly sought material for tissue engineering applications. Gelatin solution has thermoreversible gelling property which enables synthesis of biocompatible and biodegradable hydrogels and promote cell adhesion, spreading, and proliferation.

Packaging

10 mL in bottle

Legal Information

X-Pure is a registered trademark of Rousselot B.V. LLC

Storage Class Code

11 - Combustible Solids

WGK

nwg


Certificates of Analysis (COA)

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T Kirikae et al.
International journal of immunopharmacology, 19(5), 255-262 (1997-05-01)
Trace amounts of endotoxin (lipopolysaccharide: LPS) are assumed to contaminate commercially available fetal bovine serum (FBS) for tissue or cell culture during the manufacturing process. We examined how cultured cells were affected by the endotoxin and how much endotoxin was
J Ongrádi et al.
Folia microbiologica, 29(6), 450-454 (1984-01-01)
Cytotoxicity of a mixed pyrogen preparation and its components as well as native and radiodetoxified lipopolysacharides (LPS) was determined with established HEp-2 cell cultures and by measuring plating efficiency. This proved to be more sensitive to the damaging effect of
J G Brock-Utne et al.
Anaesthesia and intensive care, 17(1), 49-55 (1989-02-01)
Endotoxins (lipopolysaccharides, LPS) are potent bacterial poisons always present within the intestines in considerable amounts. Several pathophysiological conditions such as hypovolaemia, hypoxia, intestinal ischaemia, burns and radiation lead to a breakdown in the barrier and depending upon the extent of
J M Harlan et al.
Laboratory investigation; a journal of technical methods and pathology, 48(3), 269-274 (1983-03-01)
Lipopolysaccharide (LPS) produced time- and dose-dependent bovine endothelial cell injury in vitro that was manifested initially by cell detachment from culture substrate with subsequent cell lysis. Bovine endothelial cell injury was observed with LPS derived from Salmonella minnesota R595, a
Shoko Yamamoto et al.
Journal of materials science. Materials in medicine, 28(3), 48-48 (2017-02-09)
Calcium phosphate cements (CPCs), consisting of a mixture of calcium phosphate powders and setting liquid, have been widely used in orthopedic applications. One of the drawbacks of CPCs is their poor resorbability in the living body, which hinders substitution with

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