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857653

Sigma-Aldrich

trans-4-(Aminomethyl)cyclohexanecarboxylic acid

97%

Synonym(s):

AMCA, AMCHA, HAKU, TAMCHA, Tranexamic acid

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About This Item

Linear Formula:
H2NCH2C6H10CO2H
CAS Number:
1197-18-8
Molecular Weight:
157.21
Beilstein:
2207452
EC Number:
214-818-2
MDL number:
MFCD00001466
UNSPSC Code:
12352100
PubChem Substance ID:
24888448
NACRES:
NA.22

Assay

97%

form

powder

mp

>300 °C (lit.)

SMILES string

NC[C@H]1CC[C@@H](CC1)C(O)=O

InChI

1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-

InChI key

GYDJEQRTZSCIOI-LJGSYFOKSA-N

Gene Information

human ... PLG(5340)

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Application

Used as a lysine analogue to characterize binding sites in plasminogen.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Thomas Forro et al.
Cerebral cortex (New York, N.Y. : 1991), 25(5), 1228-1240 (2013-11-28)
Travelling theta oscillations and sharp wave-associated ripples (SWRs) provide temporal structures to neural activity in the CA1 hippocampus. The contribution of rhythm-generating GABAergic interneurons to network timing across the septotemporal CA1 axis remains unknown. We recorded the spike-timing of identified
Sattar Alshryda et al.
The Journal of bone and joint surgery. American volume, 95(21), 1961-1968 (2013-11-08)
Approximately one-third of patients undergoing total knee replacement require one to three units of blood postoperatively. Tranexamic acid (TXA) is a synthetic antifibrinolytic agent that has been successfully used intravenously to stop bleeding after total knee replacement. A topical application
V Sharma et al.
Anaesthesia, 69(2), 124-130 (2014-03-04)
Because of a lack of contemporary data regarding seizures after cardiac surgery, we undertook a retrospective analysis of prospectively collected data from 11 529 patients in whom cardiopulmonary bypass was used from January 2004 to December 2010. A convulsive seizure
Kristen A Matteson et al.
Obstetrics and gynecology, 121(3), 632-643 (2013-05-03)
To compare the effectiveness of nonsurgical abnormal uterine bleeding treatments for bleeding control, quality of life (QOL), pain, sexual health, patient satisfaction, additional treatments needed, and adverse events. MEDLINE, Cochrane databases, and Clinicaltrials.gov were searched from inception to May 2012.
J M Marshall et al.
Biochemistry, 33(12), 3599-3606 (1994-03-29)
The conformations of Glu-plasminogen and defined proteolytic fragments, in the presence and absence of 6-aminohexanoic acid (6-AHA), trans-4-(aminomethyl)cyclohexanecarboxylic acid (t-AMCHA), and benzamidine, were studied using three methods: size-exclusion high-performance liquid chromatography (SE-HPLC), small-angle X-ray scattering (SAXS), and dynamic laser light
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