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Sigma-Aldrich

Dowtherm® A

eutectic mixture of 26.5% diphenyl + 73.5% diphenyl oxide

Synonym(s):

Diphyl

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About This Item

MDL number:
MFCD00148859
UNSPSC Code:
12352100
PubChem Substance ID:
57650233
NACRES:
NA.22

refractive index

n20/D 1.590

mp

12-14 °C (lit.)

SMILES string

c1ccc(cc1)-c2ccccc2.O(c3ccccc3)c4ccccc4

InChI

1S/C12H10O.C12H10/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12;1-3-7-11(8-4-1)12-9-5-2-6-10-12/h1-10H;1-10H

InChI key

MHCVCKDNQYMGEX-UHFFFAOYSA-N

General description

Dowtherm® A is a thermally stable organic heat transfer fluid composed of a eutectic mixture of highly stable compounds, biphenyl, and diphenyl oxide. Dowtherm® A is suitable for high-temperature heat transfer applications up to 400 °C. This fluid can be used in both liquid and vapor phase systems.

Application

Dowtherm® A can be used as a high boiling solvent in cyclization reactions. For example, it is used to synthesize:      
  • 1-Hydroxy-5-methoxy-1,2-dihydrobenzo[f][2,7]naphthyridines from 2-chloro-3-formyl quinolines.     
  • Isoindolinone derivatives via intramolecular Diels–Alder cycloaddition reactions of substituted pyridazines.
  • Phosphorylated azaheterocycles from 2-diethoxyphosphoryl-3-methoxyacrylate via intramolecular cyclizations under thermal conditions.

Legal Information

DOWTHERM is a registered trademark of The Dow Chemical Company or an affiliated company of Dow

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H315 - H319 - H335 - H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Facile Synthesis of 1-Hydroxy-5-methoxy-Benzo [f][2, 7] naphthyridines
Rajeev PV and Rajendran SP
Synthetic Communications, 40(19), 2837-2843 (2010)
Enhancement of heat transport in thermosyphon air preheater at high temperature with binary working fluid: A case study of TEG-water.
Nuntaphan A, et al.
Applied Thermal Engineering, 22(3), 251-266 (2002)
Rolf Winter et al.
Experimental parasitology, 127(2), 545-551 (2010-11-03)
Our prior work on tricyclic acridones combined with a desire to minimize the tricyclic system led to an interest in antimalarial quinolones and a reexamination of endochin, an experimental antimalarial from the 1940's. In the present article, we show that
Thermal neutron cross sections and diffusion parameters of diphenyl and Dowtherm-A using a synthetic scattering function.
Florido PC, et al.
Journal of Nuclear Materials, 185(1), 114-122 (1999)
V M Sheĭbak et al.
Gigiena i sanitariia, (4)(4), 81-82 (2008-12-23)
Experiments on rats were carried out to study the effect of dinil on the animals on chronic intake of the agent in the quantities exceeding the maximum permissible concentrations by many times. Despite few biochemical changes, there was a certain
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