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441511

Sigma-Aldrich

N-Acetyl-L-leucine

99%, for peptide synthesis, ReagentPlus®

Synonym(s):

N-Acetyl-L-(-)-leucine, Acetylleucine

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About This Item

Linear Formula:
(CH3)2CHCH2CH(NHCOCH3)CO2H
CAS Number:
1188-21-2
Molecular Weight:
173.21
Beilstein:
1724849
EC Number:
214-706-3
MDL number:
MFCD00065131
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24867665
NACRES:
NA.22

product name

N-Acetyl-L-leucine, ReagentPlus®, 99%

product line

ReagentPlus®

Assay

99%

form

solid

optical activity

[α]25/D −23±3°, c = 2 in ethanol

reaction suitability

reaction type: C-H Activation
reaction type: solution phase peptide synthesis
reagent type: catalyst
reaction type: Peptide Synthesis

mp

187-190 °C (lit.)

application(s)

peptide synthesis

functional group

amine
carboxylic acid

SMILES string

CC(C)C[C@H](NC(C)=O)C(O)=O

InChI

1S/C8H15NO3/c1-5(2)4-7(8(11)12)9-6(3)10/h5,7H,4H2,1-3H3,(H,9,10)(H,11,12)/t7-/m0/s1

InChI key

WXNXCEHXYPACJF-ZETCQYMHSA-N

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Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Nathaniel J Traaseth et al.
The journal of physical chemistry. B, 114(43), 13872-13880 (2010-10-13)
NMR spin diffusion experiments have the potential to provide both resonance assignment and internuclear distances for protein structure determination in oriented solid-state NMR. In this paper, we compared the efficiencies of three spin diffusion experiments: proton-driven spin diffusion (PDSD), cross-relaxation-driven
Chin H Wu et al.
The Journal of chemical physics, 128(5), 052312-052312 (2008-02-13)
The acquisition and analysis of high resolution one- and two-dimensional solid-state nuclear magnetic resonance (NMR) spectra without chemical shift frequencies are described. Many variations of shiftless NMR spectroscopy are feasible. A two-dimensional experiment that correlates the dipole-dipole and dipole-dipole couplings
T Gopinath et al.
Journal of the American Chemical Society, 132(15), 5357-5363 (2010-03-30)
We present new sensitivity enhanced schemes for heteronuclear correlation spectroscopy (HETCOR) in solid-state NMR of oriented systems. These schemes will enhance the sensitivity of the HETCOR by 40% for the two-dimensional experiments (SE-HETCOR) and up to 180% for the 3D
P Benard et al.
European journal of drug metabolism and pharmacokinetics, 26(1-2), 71-76 (2001-09-14)
Acetyl-DL-leucine [2-14C]: Tanganil a antivertigal drug has been injected intravenously in two macaca monkeys which have been sacrificed 2 and 5 minutes later. Radioactivity distribution has been studied by autoradiography in the brain. An important uptake of radioactivity is localized
Alexander A Nevzorov
Journal of magnetic resonance (San Diego, Calif. : 1997), 209(2), 161-166 (2011-02-08)
Cross-polarization transfer is employed in virtually every solid-state NMR experiment to enhance magnetization of low-gamma spins. Theory and experiment is used to assess the magnitude of the final quasistationary magnetization amplitude. The many-body density matrix equation is solved for relatively
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