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404322

Sigma-Aldrich

Dichloro(1,2-diaminocyclohexane)platinum(II)

Synonym(s):

(1,2-Diaminocyclohexane)platinum(II) chloride

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About This Item

Linear Formula:
[C6H10(NH2)2]PtCl2
CAS Number:
52691-24-4
Molecular Weight:
380.17
MDL number:
MFCD00058826
UNSPSC Code:
12161600
PubChem Substance ID:
24865237
NACRES:
NA.22

reaction suitability

core: platinum
reagent type: catalyst

mp

280 °C (dec.) (lit.)

SMILES string

Cl[Pt]Cl.NC1CCCCC1N

InChI

1S/C6H14N2.2ClH.Pt/c7-5-3-1-2-4-6(5)8;;;/h5-6H,1-4,7-8H2;2*1H;/q;;;+2/p-2

InChI key

PNNCIXRVXCLADM-UHFFFAOYSA-L

Pictograms

Health hazardCorrosion
GHS08,GHS05

Signal Word

Danger

Hazard Classifications

Carc. 2 - Eye Dam. 1 - Lact. - Muta. 2 - Repr. 1B - Resp. Sens. 1B - Skin Sens. 1 - STOT RE 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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A platinum(IV) complex oxidizes guanine to 8-oxo-guanine in DNA and RNA.
S Choi et al.
Inorganic chemistry, 40(22), 5481-5482 (2001-10-16)
Sachiko Kaida et al.
Cancer research, 70(18), 7031-7041 (2010-08-06)
Nanoparticle therapeutics are promising platforms for cancer therapy. However, it remains a formidable challenge to assess their distribution and clinical efficacy for therapeutic applications. Here, by using multifunctional polymeric micellar nanocarriers incorporating clinically approved gadolinium (Gd)-based magnetic resonance imaging contrast
Horacio Cabral et al.
Journal of controlled release : official journal of the Controlled Release Society, 101(1-3), 223-232 (2004-12-14)
Block copolymer micelles, containing dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt), the oxaliplatin parent complex, were prepared through polymer-metal complex formation of DACHPt with poly(ethylene glycol)-poly(glutamic acid) block copolymer [PEG-P(Glu)] in distilled water. By dynamic light scattering (DLS) measurement, the micelle size was determined to
L M Ruiz-Perez et al.
Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 38(1), 45-48 (1987-03-01)
The trypanocidal activity of three new compounds derived of the antineoplastic drug cis-diamminodichloroplatinum(II) (DDP) has been studied over epimastigote forms of Trypanosoma cruzi. The electron microscopy indicated that, in the treated animals, the nuclear chromatin is distributed in the nucleus
Kensuke Osada et al.
Journal of the American Chemical Society, 134(32), 13172-13175 (2012-07-28)
Spontaneous formation of polymeric metallosomes with uniform size (~100 nm) was found to occur in aqueous medium through the reaction of an anticancer agent, (1,2-diaminocyclohexane)platinum(II) (DACHPt), with a Y-shaped block copolymer of ω-cholesteroyl-poly(L-glutamic acid) and two-armed poly(ethylene glycol) (PEGasus-PLGA-Chole). Circular
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