Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

235229

Sigma-Aldrich

Methyl dichlorophosphite

technical grade

Synonym(s):

Methyl phosphorodichloridite

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
CH3OPCl2
CAS Number:
3279-26-3
Molecular Weight:
132.91
Beilstein:
1697452
EC Number:
221-915-3
MDL number:
MFCD00000524
UNSPSC Code:
12352100
PubChem Substance ID:
24854089
NACRES:
NA.22

grade

technical grade

form

liquid

refractive index

n20/D 1.474 (lit.)

bp

93-95 °C (lit.)

mp

−91 °C (lit.)

density

1.376 g/mL at 20 °C (lit.)

SMILES string

COP(Cl)Cl

InChI

1S/CH3Cl2OP/c1-4-5(2)3/h1H3

InChI key

HCSDJECSMANTCX-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Application

Methyl dichlorophosphite has been employed in the preparation of:
  • phosphonamidate- and phosphonate-linked phosphonopeptides
  • 2-(2-iodophenyl)ethyl methyl phosphite derivative of an alcohol
  • deoxyoligonucleotides on a polymer support
  • cis- and trans-2-oxo-2-propionyl-1,3,2-oxazaphosphorinane
  • phosphorodichloridothioates
  • oxazaphosphorinanes

accessory

Product No.
Description
Pricing

Signal Word

Danger

Hazard Statements

H226,H314,H335

Hazard Classifications

Flam. Liq. 3 - Skin Corr. 1B - STOT SE 3

Target Organs

Respiratory system

Supplementary Hazards

EUH014

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

77.0 °F - closed cup

Flash Point(C)

25 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Nanyan Fu et al.
Journal of peptide science : an official publication of the European Peptide Society, 12(4), 303-309 (2005-10-26)
A direct method for the preparation of phosphonamidate- and phosphonate-linked phosphonopeptides has been developed. Using this method, both phosphonopeptides were prepared in acceptable yields directly from simple and commercially available chemicals in one-pot reactions of benzyl carbamate, aldehydes, and methyl
Synthesis of deoxyoligonucleotides on a polymer support.
Matteucci MD and Caruthers MH.
Journal of the American Chemical Society, 103(11), 3181-3191 (1981)
Synthesis and enantioselective aldol reaction of a chiral 2-oxo-2-propionyl-1, 3, 2-oxazaphosphorinane.
Gordon NJ and Evans Jr SA.
The Journal of Organic Chemistry, 58(20), 5295-5297 (1993)
T Tanaka et al.
Nucleic acids research, 10(10), 3249-3260 (1982-05-25)
A simple procedure is described for synthesis of oligonucleotides by phosphate chemistry. Chains can be constructed rapidly with minimal equipment (a syringe and reagent bottles). The method is illustrated by synthesis of d-TGCAGGTT. Pertinent supporting data on the effect of
Liming Zhang et al.
Journal of the American Chemical Society, 126(41), 13190-13191 (2004-10-14)
A highly efficient, two-step sequence method for the deoxygenation of hydroxyl groups has been developed. The method involves the preparation of the 2-(2-iodophenyl)ethyl methyl phosphite derivative of an alcohol using methyl dichlorophosphite and 2-(2-iodophenyl)ethanol. Treatment of the phosphite intermediate with
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service