157864

1-Acetylimidazole

98%

• Synonym(s): 1-(1H-Imidazol-1-yl)ethan-1-one, 1-(1H-Imidazol-1-yl)ethanone, 1-Acetyl-1H-imidazole, N-Acetylimidazole
• Empirical Formula (Hill Notation): C₅H₆N₂O
• CAS Number: 2466-76-4
• Molecular Weight: 110.11
• Beilstein: 108425
• EC Number: 219-577-7
• MDL number: MFCD00005287
• UNSPSC Code: 12352005
• PubChem Substance ID: 24849704
• NACRES: NA.22

Properties

• Quality Level: 200
• Assay: 98%
• form: solid
• mp: 99-105 °C (lit.)
• solubility: water: soluble 50 mg/mL, clear, colorless
• storage temp.: 2-8°C
• SMILES string: CC(=O)n1ccnc1
• InChI: 1S/C5H6N2O/c1-5(8)7-3-2-6-4-7/h2-4H,1H3
• InChI key: VIHYIVKEECZGOU-UHFFFAOYSA-N

Description

General description

Rate of solvolysis of 1-acetylimidazole in acid solutions was evaluated. Reaction of 1-acetylimidazole with orthophosphate and adenosine-5′-phosphate has been reported.

Application

1-Acetylimidazole was used as acetylation reagent for amino groups. It was also employed for acetylation of histones.

Relatively specific reagent for tyrosyl residue acetylation. Reagent used in the synthesis of annulated imidazole derivatives.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves