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113727

Sigma-Aldrich

Norphenylephrine hydrochloride

98%

Synonym(s):

α-Aminomethyl-3-hydroxybenzyl alcohol hydrochloride, 3,α-Dihydroxyphenethylamine hydrochloride, Norfenefrine hydrochloride

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About This Item

Linear Formula:
HOC6H4CH(CH2NH2)OH · HCl
CAS Number:
4779-94-6
Molecular Weight:
189.64
EC Number:
225-323-6
MDL number:
MFCD00012879
UNSPSC Code:
12352100
PubChem Substance ID:
24847145
NACRES:
NA.22

Assay

98%

form

solid

mp

162-164 °C (lit.)

SMILES string

Cl.NCC(O)c1cccc(O)c1

InChI

1S/C8H11NO2.ClH/c9-5-8(11)6-2-1-3-7(10)4-6;/h1-4,8,10-11H,5,9H2;1H

InChI key

OWMFSWZUAWKDRR-UHFFFAOYSA-N

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Application

Norphenylephrine hydrochloride was used in the study of the effects of phenylephrine on the isolated heart of rabbit.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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L Jørgensen et al.
Urologia internationalis, 46(2), 176-179 (1991-01-01)
To study the acute effect of norfenefrine, given orally in aqueous solution, on the urethral closure function, profilometry was performed before and after administration of placebo and increasing doses of norfenefrine in 6 females with genuine stress incontinence. A weak
M R Gaab et al.
Advances in neurology, 52, 391-400 (1990-01-01)
We investigated the effects of the calcium entry blocker nimodipine on cerebral autoregulation, BBB, and vasogenic edema in animal experiments. In the first series of rats, ICBF was measured with H2 clearance using a balanced multiwire surface electrode. Variations in
R B Raffa et al.
European journal of pharmacology, 169(2-3), 317-320 (1989-10-10)
Administration of p-octopamine by intracerebroventricular (i.c.v.) or intrathecal (i.t.) routes, but not orally, produced antinociception in the acetylcholine-induced abdominal constriction test (ED50 = 24.8 and 3.6 micrograms, respectively). Likewise, i.c.v. and i.t., but not peripheral (up to 200 mg/kg s.c.)
O Oldenburg et al.
Deutsche medizinische Wochenschrift (1946), 124(1-2), 8-12 (1999-02-10)
A 71-year-old man was admitted because of treatment-resistant orthostatic hypotension of unknown aetiology. When aged 64 years he developed some impotence and later urinary incontinence and urinary frequency. At 68 years he noted vertigo on physical activity, and a year
J F Coulon et al.
Journal of neurochemistry, 52(5), 1418-1424 (1989-05-01)
Phenolamines, particularly octopamines, are of special importance in avoidance behavior. In the Roman low avoidance (RLA) strain, p-octopamine can induce locomotor behavioral activity that is normally observed in the Roman high avoidance (RHA) strain. For these reasons, the levels of
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