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104051

Sigma-Aldrich

Picolinamide

98%

Synonym(s):

2-Pyridinecarboxamide

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About This Item

Empirical Formula (Hill Notation):
C6H6N2O
CAS Number:
1452-77-3
Molecular Weight:
122.12
EC Number:
215-921-5
MDL number:
MFCD00023483
UNSPSC Code:
12352100
PubChem Substance ID:
24846635
NACRES:
NA.22

Assay

98%

mp

110 °C (dec.) (lit.)

SMILES string

NC(=O)c1ccccn1

InChI

1S/C6H6N2O/c7-6(9)5-3-1-2-4-8-5/h1-4H,(H2,7,9)

InChI key

IBBMAWULFFBRKK-UHFFFAOYSA-N

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Application

Picolinamide was used as template in preparation of molecular imprinting polymer. Picolinamide was used in a study to evaluate kinetics and mechanism of liberation of picolinamide from chromium(III)-picolinamide complexes in HClO4.

Biochem/physiol Actions

Picolinamide is potential inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. Picolinamide acts as bidentate ligand and forms complexes with lanthanide nitrates, thiocyanates and perchlorates.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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T Kawabata et al.
Acta pathologica japonica, 42(7), 469-475 (1992-07-01)
The effects of three isomers of pyridinecarboxamide (picolinamide (2-pyridinecarboxamide), nicotinamide (3-pyridinecarboxamide) and isonicotinamide (4-pyridinecarboxamide)) on iron-induced renal damage were studied. Pyridinecarboxamide (250 mg/kg body weight, ip) was administered 10 min before injection of ferric nitrilotriacetate (Fe(III)-NTA) (7.5 mgFe/kg body weight
Protection by picolinamide, a novel inhibitor of poly (ADP-ribose) synthetase, against both streptozotocin-induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets.
H Yamamoto et al.
Biochemical and biophysical research communications, 95(1), 474-481 (1980-07-16)
Lanthanide complexes with picolinamide.
Condorelli G, et al.
J. Inorg. Nucl. Chem., 36(12), 3763-3766 (1974)
Hongguang Liu et al.
Journal of medicinal chemistry, 56(3), 895-901 (2013-01-11)
Melanoma is an aggressive skin cancer with worldwide increasing incidence. Development of positron emission tomography (PET) probes for early detection of melanoma is critical for improving the survival rate of melanoma patients. In this research, (18)F-picolinamide-based PET probes were prepared
Electine Magoye et al.
Antibiotics (Basel, Switzerland), 9(9) (2020-09-19)
Many yeasts have demonstrated intrinsic insensitivity to certain antifungal agents. Unlike the fungicide resistance of medically relevant yeasts, which is highly undesirable, intrinsic insensitivity to fungicides in antagonistic yeasts intended for use as biocontrol agents may be of great value.
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